Analytics
A system-wide approach for the identification of druggable proteins in a complex mixture
Ref.-Nr.: 0402-5163-MG
Analytics
In contrast to target-based drug discovery, phenotypic screening discloses the effect of a compound on a biological system without revealing its mode of action or its interaction sites. Phenotypic screening has delivered several new valuable drugs, however, the major challenge remains target deconvolution (1). In recent years, “omics” techniques and bioinformatics have brought significant advances to target identification in drug discovery phenotypic screening. However, such analyses can become ...
Read more … A system-wide approach for the identification of druggable proteins in a complex mixture
Automated real time determination of crystal size and 3D shape distribution to quantify and predict the properties and dynamics of the crystallization processes
Ref.-No.: 1402-5690-LC
Analytics
Processes and Methods (incl. Screening)
To monitor crystallization processes a special camera setup to measure the crystal size and 3D shape distribution was developed.
The setup consists of two high-speed cameras that are positioned orthogonally to one another such that a precise overlap of both fields of view can be achieved. The setup further contains a specially designed flow-through cell that allows to observe the crystal suspension from both camera directions and given the opportunity to temperate the solution within the cell. ...
BiQ Analyzer Software for DNA Methylation Analysis, Visualization and Quality Control
Ref.-No.: 1200-3727-GÖ
Analytics
BiQ Analyzer is a software tool for easy visualization and quality control of DNA methylation data. With more than a thousand users worldwide, BiQ Analyzer has become a standard tool for processing DNA methylation data from bisulfite sequencing. BiQ Analyzer has been selected by ABI to be part of the Applied Biosystems Software Community Program.
Read more … BiQ Analyzer Software for DNA Methylation Analysis, Visualization and Quality Control
Dynamic control of three-dimensional light distributions through wavefront engineering: hardware and software system
Ref.-No.: 0202-5001-LI
Analytics
IT / Software / Bioinformatics
Engineering light distributions in a three-dimensional volume to achieve selective illumination profiles is an instrumental task shared by many optical and microscopy techniques. The optimization of the light distribution can lead to significant enhancement of relevant performance figures and ultimately to the extension of the instrument or experimental protocol capabilities1,2,3,4,5. Targeted illumination profiles can be used either to mechanically interact with molecules at nanometer ...
Homogenous, TR-FRET-based method for measurement of RNA- and DNA-polymerase activity
Ref.-No.: 1013-4990-IKF
Analytics
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Nucleic Acid-, Protein and Cell-related Technologies : Protein related
Nucleic Acid-, Protein and Cell-related Technologies : Cell related
An innovative high throughput screening method for measurement of RNA- and DNA-polymerase activity at room temperature, based on time-resolved FRET.
Read more … Homogenous, TR-FRET-based method for measurement of RNA- and DNA-polymerase activity
Nanographene-based dyes as high performance probes for super-resolution microscopy
Ref.-Nos.: 0903-5658-LC; 0903-5696-LC
Analytics
Imaging and Microscopy
New Materials
A group of scientists at the MPI for Polymer Research in Mainz developed nano-graphene structures that can be used as a new class of fluorophores for super-resolution microscopy (SMLM and STED).
They perform like hybrids of organic dyes and QDs: they have excellent environment-independent blinking properties, emit high photon numbers, display high photo-stability, possess low toxicity, have a molecular size below 2 nm, and have narrow excitation and emission spectra.
These nanographene ...
Read more … Nanographene-based dyes as high performance probes for super-resolution microscopy
New KDAC assay and selection system
Ref.-No.: 0803-5480-IKF
Analytics
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine : Diagnostics
Nucleic Acid-, Protein and Cell-related Technologies : Protein related
We present an extremely sensitive, reliable and fast novel Lysine deacetylase (KDAC) assay, which can be performed in a continuous format. This novel KDAC assay is based on Firefly luciferase harboring an acetylation on an essential active site lysine, incorporated by genetic code expansion.
We furthermore offer a bacterial selection system that can help engineer KDACs. The selection system uses a reporter enzyme inactivated by lysine modifications at an essential active site residue, thereby ...
Novel Biomarkers for Ageing and Metabolic Health
Ref.-Nr.: 1013-5354-IKF
Analytics
Medicine : Therapeutics
Medicine : Diagnostics
Research Tools : Other
Nucleic Acid-, Protein and Cell-related Technologies : Cell related
Biomarkers of ageing have long been sought after to help assess the biological age and general health status of individuals. Considerable efforts have been invested to identify such biomarkers, including physiologic readouts, metabolic parameters, glycomic profiles and others. Nevertheless, markers with strong predictive power have remained elusive.
Work in model organisms has identified several conserved signaling pathways that extend life span, such as reduced insulin/IGF signaling and ...
Read more … Novel Biomarkers for Ageing and Metabolic Health
Novel method for analysis of complex carbohydrate structures by ion-mobility mass spectrometry (IM-MS)
Ref.-Nr.: 0401-5070-MG
Analytics
Carbohydrates form one of the major classes of biological macromolecules in living organisms, but structural analysis and the quality control of carbohydrate structures represent a major challenge due to the frequent occurrence of isomers that are difficult to distinguish using established techniques.
Changes in protein glycosylation are frequently identified in the context of diseases. For example, alterations in N-glycan profiles from blood plasma have been found to correlate with pathological ...
Predicting concentrations, reactions rates and rate constants in biochemical networks
Ref.-No.: 0402-5469-MG
Analytics
IT / Software / Bioinformatics : Bioinformatics
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Nucleic Acid-, Protein and Cell-related Technologies : Protein related
A computer-implemented method that allows calculating concentration ranges of components within complex networks of biochemical reactions.
Read more … Predicting concentrations, reactions rates and rate constants in biochemical networks
Simple, one-step assay for reliable measurements of NAD(H) and NADP(H) in complex samples
Ref.-Nr.: 0105-5434-IKF
Analytics
A simple, one-step assay for reliable measurements of NAD(H) and NADP(H) in complex samples, with various applications such as enzymatic assays, clinicals tests, and as point of care tests in the field of ageing.
Stable, site-specific conjugation of His-tagged proteins via cobalt (III) carbonate reagents
Ref.-No.: 0105-5774-IKF
Analytics
Processes and Methods (incl. Screening) : Chemical
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Research Tools : Other
Nucleic Acid-, Protein and Cell-related Technologies : Protein related
This invention relates to means and methods for conjugating/attaching target molecules such as proteins to a label and/or carrier.