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Scienion´s sciDROP PICO technology is a proprietary dispensing technology for microarray spotting which enables dispensing a liquid sample from 10 pL to 800 pL per drop. © Scienion

Cellink, the Swedish bioprinting company, has purchased Scienion AG, a spin-off of the Max Planck Institute (MPI) for Molecular Genetics based in Berlin. The purchase price was 80 million euros. The Max Planck Society (MPG) will now receive significant proceeds from the sale of its shares. Cellink intends to use the acquisition to drive future growth in industrial and clinical applications.

The proteasome is a hollow cylinder consisting of 28 subunits, which are shown in color here in the ligament model. Inside the molecule are the active centers as binding sites for various inhibitors (white). The proteasome is degrading proteins that are no longer required and therefore plays an important role in cell regulation. Novel proteasome inhibitors with unique binding characteristics should create the basis for new therapies for the treatment of cancer, inflammation and autoimmune diseases. Illustration: Robert Huber © MPI of Biochemistry

The Lead Discovery Center GmbH (LDC) and the South Korean drug development specialist Qurient have founded QLi5 Therapeutics GmbH, together with the LDC’s partners, the Max Planck Society (MPG) and Nobel laureate Prof. Huber, emeritus director of the Max Planck Institute for Biochemistry. Dortmund based QLi5 Therapeutics licensed novel proteasome inhibitors from LDC and its partners. QLi5 Therapeutics will advance these towards preclinical and clinical development for the treatment of cancers and inflammatory and autoimmune disorders.

® RFBSIP/Adobe Stock

The biotech company Qurient Co. Ltd. received a clearance from the U.S. Food and Drug Administration (FDA) for its investigational new drug application (IND) for Q702. The technology for the orally available immuno-oncology therapeutic small molecule, targeting different tyrosine kinases, originated from the Max Planck Institute of Biochemistry. Qurient plans to initiate a Phase 1 clinical study in patients with advanced solid tumors for whom standard of care therapies are currently ineffective.

Christoph Rademacher’s (right) research group at the Max Planck Institute of Colloids and Interfaces. © MPI of Colloids and Interfaces

The Max Planck Institute of Colloids and Interfaces in Potsdam and the Technology Transfer Fund KHAN-I are developing a vaccine procedure for SARS-CoV2 together with the Lead Discovery Center in Dortmund. The researchers hope that within the next few years, they will be able to establish immunity to and protection from the virus using targeted vaccine transport via the skin.

AIDS (Acquired Immune Deficiency Syndrome) is a combination of symptoms that occur as a result of infection with HIV (Human Immunodeficiency Virus) and the associated destruction of the immune system. Patients suffer from life-threatening infections and tumors. ® nobeastsofierce/Adobe Stock

Hamburg-based researchers are seeking to improve future treatment of HIV patients using a new gene and cell method. Under the umbrella of Hamburg biotech startup Provirex, they are developing a new therapeutic approach that uses ‘gene scissors’ to cut out the blueprint of the AIDS pathogen HIV from the genome of the infected cell and eliminate the virus. For the first time, this could make it possible to remove the virus instead of keeping it at bay, as is common with previous forms of treatment. The startup will drive further development of Brec1 technology, particularly with regard to simplified and direct routes of administration. A Max Planck technology contributes to innovative basis for the HIV gene scissors.

GIVLAARI™ (givosiran) product and packaging (picture: Business Wire)

Every year, Max Planck Innovation evaluates an average of 120 inventions, with roughly half of these leading to a patent application. Since 1979, approximately 4,450 inventions have been accompanied and around 2,680 exploitation contracts have been concluded. Since the early 90s, 156 newly founded companies (spin-offs) have emerged from the Max Planck Society. Max Planck Innovation advised the vast majority of them. Over 6,000 jobs have been created in these spin-offs since then. Since 1979, MI has achieved a total turnover from license revenues and divestments of around 490 million euros.

Neutrophil granulocytes
Scientists at the MPI for Infection Biology have discovered a previously unknown mechanism: neutrophil granulocytes, cells that form part of the human immune system, can cast a sort of net to capture bacteria and kill them outside the cell. The red invaders – in this case Shigella bacteria – become entangled in the yellow nets. © Volker Brinkmann/MPI for Infection Biology

The Lead Discovery Center GmbH (LDC), the Max Planck Society (MPG) and Max Planck Innovation (MI) announce that their associated company Quench Bio Inc., Cambridge, USA has raised USD 50 million in a Series A financing round. The financing was led by RA Capital Management (RA Capital) and included Abbvie Ventures as well as co-founders and seed investors Atlas Venture (Atlas) and Arix Bioscience plc (Arix).

Bacteria of the attenuated tuberculosis vaccine strain (BCG) inside a macrophage, a scavenger of the immune system. Source: MPI for Infection Biology - CF Microscopy / Volker Brinkmann

The human immune system can recognize and eliminate not only germs but also cancer cells. This is why treatments with weakened germs can help the immune system in its fight against cancer. Researchers at the Max Planck Institute for Infection Biology in Berlin have genetically modified the tuberculosis vaccine BCG in a way that it stimulates the immune system more specifically. Consequently, the new vaccine offers much greater protection against tuberculosis. A clinical study with patients suffering from cancer of the bladder has now shown that a therapy with VPM1002 could successfully prevent the recurrence of tumours in almost half of the patients who had not responded previously to the BCG therapy. The results could lead to the early approval of the drug for the treatment of cancer of the bladder so that as many patients as possible can profit from this quickly.

® fotoliaxrender / Adobe Stock

Tacalyx, a biotech company focused on the discovery and development of novel anti-TACA (Tumor Associated Carbohydrate Antigens) cancer therapies, today announced that it has successfully secured €7 million in seed funding. The funding round involves a syndicate of leading European life science and technology investors co-led by Boehringer Ingelheim Venture Fund and Kurma Partners and joined by Idinvest Partners, High-Tech Gründerfonds (HTGF), coparion, and Creathor Ventures.

© Gorodenkoff / Adobe Stock

Khanu Management GmbH (Khanu), a drug discovery focused fund management team, announces the successful launch of KHAN Technology Transfer Fund I GmbH & Co KG (KHAN-I), based in Dortmund, Germany.

® Simone van der Koelen

Modag further develops drugs for multi-system atrophy and Parkinson’s disease. The protein alpha-synuclein is deposited in the brain of patients with Parkinson’s disease or multi-system atrophy at the onset of the disease. Oligomeric deposits have a particularly toxic effect on nerve cells. With a new patent for chemically modified drug candidates, Modag has now agreed upon another exclusive license with Max Planck Innovation, the technology transfer organization of the Max Planck Society. The company is now testing the active ingredient anle138b for the treatment of multi-system atrophy and Parkinson’s disease. On the basis of the licensed technology, Modag is able to develop next-generation-molecules with pharmacological characteristics, which allow for alternative dose regimens and forms of application. The substances were developed by researchers at the Max Planck Institute for Biophysical Chemistry in Göttingen together with the University in Munich.

Analytical diligence: Filled in sample vials, potential drug candidates undergo extensive tests (© LDC)

In 2008, the Max Planck Society launched the Lead Discovery Center (LDC) in Dortmund. The organization, which is now independent, picks up on the results of basic research and uses them to develop substances that can then be tested by license or cooperative partners in clinical studies with the aim of establishing whether they are suitable for use in drugs. Ten years after its establishment, the LDC can look back on some impressive results: one of its research projects has managed to make the leap to the clinical stage and is currently being tested in a phase 1b study; two others will be following soon. In all, the LDC has filed 23 patent applications and granted licenses to cooperative partners for research into 15 more substances.

Viruses can be useful aides in cancer therapy since they are able to infect and kill tumor cells. Themis Bioscience will now develop, manufacture and commercialize therapies based on an oncolytic measles virus platform. (© guerrieroale – Fotolia)

Themis announced today that it has entered into a license agreement with Max Planck Innovation GmbH, the technology transfer agency of the Max Planck Society in Germany, granting it exclusive worldwide license to develop, manufacture and commercialize therapies based on an oncolytic measles virus platform that was jointly developed by the Eberhard-Karls-University Tübingen and the Max Planck Institute for Biochemistry. Financial terms of the agreement were not disclosed.

RNAi Therapeutic for the treatment of the polyneuropathy of Hereditary Transthyretin-Mediated Amyloidosis in adults (© Alnylam)

Alnylam Announces First-Ever FDA Approval of an RNAi Therapeutic, ONPATTRO™ (patisiran) for the Treatment of the Polyneuropathy of Hereditary Transthyretin-Mediated Amyloidosis in Adults Alnylam Pharmaceuticals, Inc. the leading RNAi therapeutics company, announced that the United States Food and Drug Administration (FDA) approved ONPATTRO™ (patisiran) lipid complex injection, a first-of-its-kind RNA interference (RNAi) therapeutic, for the treatment of the polyneuropathy of hereditary transthyretin-mediated (hATTR) amyloidosis in adults. ONPATTRO is the first and only FDA-approved treatment for this indication. The therapy is, among others, based on patented research findings from the Max Planck Society, which have exclusively been licensed to Alnylam by the technology transfer organization Max Planck Innovation. In addition to polyneuropathy, hATTR amyloidosis can lead to other significant disabilities including decreased ambulation with the loss of the ability to walk unaided, a reduced quality of life, and a decline in cardiac functioning. In the largest controlled study of hATTR amyloidosis, ONPATTRO was shown to improve polyneuropathy –with significant benefit on the neurological components of the disease in a majority of patients – and to improve a composite quality of life measure, reduce autonomic symptoms, and improve activities of daily living.

Ultra-thin gold fibers with a thickness of less than 10 microns manufactured with the innovative Micro Metal Fiber Technology (© BinNova Metal Fiber Technology GmbH)

The BinNova Metal Fiber Technology GmbH company has licensed a technology from the Max Planck Institute for Medical Research, which makes it possible to produce micro-metal fibers that are extremely fine and, at the same time, extremely robust. Following the successful development of the research concept and a research facility by the Max Planck Institute for Medical Research, the company will now begin developing a production facility and will very soon commence distribution of the innovative metal fibers and non-wovens.

The seeds of the milk thistle (Silybum marianum) contain Silibinin, a compound, which could be used against Morbus Cushing. The annual or biennial weed grows along waysides, dumps and pastures around the Mediterranean (© Curtis Clark – Wikipedia)

The pharmaceutical company IBI (Istituto Biochimico Italiano Giovanni Lorenzini SpA) obtained a license from Max Planck Innovation for the use of Silibinin in the treatment of Cushing´s disease. Based on research findings from the Max Planck Institute of Psychiatry IBI aims to develop a non-invasive treatment option replacing conventional methods like pituitary surgery. IBI is now planning GLP preclinical trials and initiates orphan drug application.

© science photo - Fotolia

Grünenthal, Lead Discovery Center GmbH (LDC), Max-Planck Innovation and the Max Planck Institute of Experimental Medicine (MPI-EM) have entered into a research collaboration to develop novel therapies for patients suffering from Charcot-Marie-Tooth 1A (CMT1A), an inherited neurological disorder. The collaboration combines the disease proficiency of MPI-EM, the drug discovery expertise of LDC and Grünenthal’s competency in drug discovery and development as well as pain management. The project’s scientific foundation was laid at MPI-EM by Michael Sereda, Klaus-Armin Nave and Moritz Rossner.

Thanks to Jens Frahm and his team, MRI scans can today be performed relatively quickly (© Frank Vinken)

With the European Inventor Award 2018, the European Patent Office (EPO) honored Jens Frahm of the Max Planck Institute (MPI) for Biophysical Chemistry in Göttingen for his ground-breaking advances in magnetic resonance imaging (MRI). In two steps, the physicist and his team succeeded in speeding up MRI by a factor of up to 10,000 and established it in clinical practice.

Rost verursacht jedes Jahr weltweit Kosten in Milliardenhöhe © Kevin Clark

The company ENVIRAL® Oberflächenveredelung GmbH has licensed a corrosion protection technology from the Max Planck Institute of Colloids and Interfaces based on recent developments in the field of nanotechnology. The new smart pigments for use in anticorrosion coatings have “self-healing” properties and increase the protective effect of coatings while improving their environmental compatibility. They are based on micro- and nanovessels that are filled with organic corrosion inhibitors and encapsulated in a polyelectrolyte shell. The tiny vessels can be added to paints without weakening the physical properties of the anticorrosion coating. Local pH changes due to the onset of corrosion causes the polyelectrolyte shell to swell and release the corrosion-inhibiting agents from the tiny vessels, thus nipping the corrosion reaction in the bud.

The ProteoPlex MacroDSF analyzer for structural analysis of macromolecular complexes. © ProteoPlex

ProteoPlex has exclusively licensed a technology from the Max Planck Institute for Biophysical Chemistry in Göttingen and has launched the MacroDSF, an instrument aimed at helping research institutions, pharmaceutical companies and contract research organisations solve problems in structural biology. In addition, ProteoPlex has also gained access to additional technologies, including a novel protein purification process and an algorithm for determining the optimum stability parameters for macromolecular proteins.

Ambiverse has developed an intelligent software solution for the automatic and accurate detection and resolution of ambiguous words and phrases in texts. © Headwayio

Based on research by the Max Planck Institute for Informatics, Ambiverse has developed a software application that can understand and analyze large volumes of text. The technology means that homonyms can be correctly interpreted, opening up corporate access to more relevant information on the Internet and improving access to information in their own data inventories.

The technology of Aircloak makes it possible to evaluate data from users and customers in accordance with data protection, since no conclusions can be drawn on individuals. © Charles Deluvio

Aircloak, a leader in the field of privacy enhancing technology received a $1.3M equity investment from Speedinvest and Constantia New Business with existing shareholders Max Planck Innovation and Elephant & Castle Capital joining the round. The “Aircloak Insights” solution, which allows companies worldwide to have GDPR compliance at a click, has been approved by the independent French data protection authority, CNIL, for all data types and use cases. Aircloak was founded in 2014 to commercialize and build on privacy protection research done at the Max Planck Institute for Software Systems.

The CAN-Q is a versatile analysis platform with a new readout based on electrical cell properties (CAN-Spectroscopy). © Venneos

Venture capital fund BORN2GROW has invested in Stuttgart-based Venneos GmbH, a spin-off from Max Planck Society, in the current round of series A financing. The start-up is successfully developing and marketing the CAN-Q – a silicon chip-based imaging system for analysing biological cells.

Daiichi Sankyo, Max Planck Innovation GmbH and the Lead Discovery Center GmbH have signed an agreement providing Daiichi Sankyo with the option to receive the exclusive rights to a new lead compound for the treatment of cancer to be discovered and developed at the Lead Discovery Center.

The new process licensed by us to Fluxpharm can cut drug production costs by 25 percent or more. © Freestocks

The company FluxPharm has acquired a licence for a chemical process developed at the Max Planck Institute of Colloids and Interfaces in Potsdam. Using flow chemistry technology, the researchers at the Institute can now produce a variety of standard ingredients with much greater efficiency and more cost-effectively than with conventional methods. FluxPharm now intends to develop the technology and make it commercially available. The development of this process will boost the future production of Efavirenz, an active pharmaceutical ingredient used in the treatment of HIV. This in turn will mean that greater numbers of people in poor countries will have access to medications. The relevant negotiations with drug-producing companies are already at an advanced stage.

Multi-resistant germs pose major challenges for medicine. terraplasma medical develops a product for the treatment of chronic and acute wounds with cold plasma (© Wikimedia: Eric Erbe, Christopher Pooley)

The Munich-based medical technology company terraplasma medical GmbH successfully completed the first round of major financing (seed). The raised money, a seven-figure Euro amount, will be used to develop plasma care and establish the market approval. This mobile, battery-powered medical device for in- and outpatient treatment of chronic and acute wounds using cold plasma, which destroys fungi and even multi-resistant bacteria, is based on research of the Max Planck Institute for extraterrestrial Physics.

In heart failure, the heart is unable to deliver the amount of blood needed by the body without increasing pressure in the atria. © Rawpixwl

Cardior Pharmaceuticals today announced the completion of a €15 million series A financing round. Cardior is pioneering its proprietary RNA technology to revolutionize predicting and treating heart failure. The main technology is based on research from the Medical School Hannover (MHH) in cooperation with the Max Planck Institute for biophysical chemistry in Göttingen, amongst others.

Thanks to a new algorithm, Apollo constantly adjusts its movements to current requirements. © Max Planck Institute for Intelligent Systems / N. Ratliff

The technology transfer organisation of the Max Planck Society has come to an agreement with the US start-up company Lula Robotics to use a technology for “continuous motion optimization and control”. Based on the technique from the Max Planck Institute for Intelligent Systems in Tübingen Lula Robotics is developing robots, which can act independently in complex environments. The goal is to create the bedrock for artificial aides supporting people in everyday life in the future.

© Ascenion

On 22 and 23 May, Max Planck Innovation will present two promising inventions at the BioVaria technology fair in Munich, one of which is a new therapy based on adult stem cells that makes continuous skin regeneration and the sustainable growth of new hair possible. An innovative diagnostic approach allows early non-invasive detection of lung cancer by means of a simple breath test. The technology transfer organization of the Max Planck Society is looking for industrial partners at the fair to develop its patented technologies to market maturity.

The iST kit from PreOmics accelerates the preparation of samples for mass spectrometry. © PreOmics

The start-up company PreOmics licenses several technologies of the Max Planck Institute of Biochemistry in Martinsried for the preparation of samples for proteomic research through Max Planck Innovation. In particular, an innovative sample preparation kit facilitates the use of mass spectrometry for research into proteins. In the future this could open up new opportunities in pharmaceutical development and diagnostics.

Thanks to the FLASH technology invented by Prof. Jens Frahm, MRI is today the most important imaging procedure in clinical diagnostics and is used worldwide. With FLASH 2 even real-time MRI movies are the beating (© MPI for biophysical chemistry)

The physicist Jens Frahm, head of Biomedizinische NMR Forschungs GmbH at the Max Planck Institute for Biophysical Chemistry in Göttingen, has been inducted into the Hall of Fame of German Research. With this induction, ‘manager magazin’ is honouring the researcher for his pioneering further developments of magnetic resonance imaging (MRI). The FLASH technology he invented has made MRI today’s most important imaging method in clinical diagnostics and one which is used around the globe. An extension, which Frahm developed only recently, is now even enabling real-time recordings from the inside of the body, and is currently being tested for clinical use.

Tom Monroe (right), Managing Director of Vaxxilon, with Stefan von Holtzbrink, Chairman of the Jury, at the Science Start-up of the Year 2016 © Falling Walls Venture

Under the motto "Building bridges, transcending borders", 23 start-up companies presented their research projects at the Falling Walls Venture science competition on 8 November in Berlin. The company nominated by Max Planck Innovation, Vaxxilon, emerged as the winner and was proclaimed the "Science Start-Up of the Year 2016" for its development of a carbohydrate-based agent. The new agent should make vaccinations against bacterial infections cheaper in the future and thereby also improve access to vaccines in poorer countries.

© whitehoune -

Light-sensitive proteins discovered by Max Planck scientists are changing the way scientists study how new drug candidates affect critical properties of heart and nerve cells. Researchers can incorporate light-sensitive channelrhodopsin proteins into model cells grown in miniature test tube arrays. Using an instrument developed by Photoswitch Biosciences Incorporated, these light-sensitive ion channels can then be used to control the function of other ion channels of interest. Monitoring tiny electrical changes in the cells allows researchers to screen chemical libraries for new drug candidates or to evaluate the safety of new drugs for use in humans.

Figure 1: Protected STED microscopy provides images with unprecedented contrast and dynamic range. (Courtesy of MPI for Biophysical Chemistry.)

STED microscopy is a Nobel Prize awarded technology that allows to create highly resolved fluorescence images far below the diffraction limit. Earlier this year, researchers at the Max Planck Institute for Biophysical Chemistry in Göttingen have proposed and demonstrated their new Protected STED concept which enhances the image contrast and reduces photobleaching in STED microscopy by up to an order of magnitude. It is expected that their invention will particularly boost life-cell and medical applications of STED microscopy.

Schizophrenia is a severe mental illness that greatly affects the personality of the sufferer, their behavior, thinking and perception of the world. ©TeamDaf / Adobe stock

The Lead Discovery Center GmbH (LDC), Max Planck Innovation GmbH and Boehringer Ingelheim International GmbH have signed an agreement providing Boehringer Ingelheim with the option to receive the exclusive rights to a new lead compound for the treatment of schizophrenia to be discovered and developed at the LDC.

© TechnologieAllianz

Max Planck Innovation together with six other new members reinforces the nationwide Verband für Wissens- und Technologietransfer (Federation for the Transfer of Knowledge and Technology) from German universities and research facilities. The country's largest network for the exploitation of research results from the German scientific community offers industry access to Germany´s largest pool of patented high technology.

© Venneos

Venneos GmbH is based in Stuttgart and develops a novel imaging system for the analysis of biological cells. A consortium of business angels and family offices, along with the High-Tech Gründerfonds and Max Planck Society invest in the company to develop a market-ready product and prepare the market entry of the first product generation.

© Peter Seeberger (David Ausserhofer/MPIKG)

Sugar does not just make vaccines sweet. Some vaccines owe their effect to carbohydrates, to which sugar belongs. Vaxxilon, a company jointly founded by the Max Planck Society and the Swiss firm Actelion Ltd, will carry out research and development of these carbohydrate-based vaccines and bring them to market. The synthetic vaccines will primarily provide protection against bacterial infections. With a view to launching them on the market, Vaxxilon has acquired the exclusive rights to various preclinical vaccine candidates and methods from Max-Planck-Innovation GmbH, the Max Planck Society’s technology transfer company. The scientific basis for Vaxxilon’s business model was established by a team of scientists headed by Peter Seeberger, Director at the Max Planck Institute of Colloids and Interfaces in Potsdam/Golm.

Laboratoy at Lead Discovery Center (© LDC)

The Lead Discovery Center GmbH (LDC), a renowned translational drug discovery organization established by Max Planck Innovation, and Qurient Co., Ltd have signed a licence deal providing Qurient with exclusive worldwide rights to a series of highly-selective CDK7 inhibitors discovered at the LDC for the treatment of cancer, inflammation and viral infections. The partners will closely collaborate to advance the approach from the validated lead stage into clinical development. Upon successful proof-of-concept in humans they will jointly identify a suitable partner for follow-on licensing.

© IT Inkubator

The ideas and inventions arising from research projects of the joint venture between Max Planck Society and Saarland University’s computer science department will in future to be further developed on campus and then marketed for application. Scientists can either set up their own companies or develop the technology to the stage where established businesses can purchase these licenses. In support of these scientists, Max Planck Society and Saarland University co-founded the IT Inkubator GmbH to create structures, which inventors and young entrepreneurs need in order to bring new technologies to market.

Prof. Dr. Stefan W. Hell (© MPI for biophysical chemistry)

Stefan W. Hell, Director at the Max Planck Institute for Biophysical Chemistry in Göttingen has been awarded this year’s Nobel Prize in Chemistry. He shares the prize with Eric Betzig and William E. Moerner.

The electron microscopic image of a mouse retina demonstrates that using the KonTEM phase contrast system (right) makes previously invisible structures visible.

KonTEM GmbH, an HTGF-financed spin-off of the Max Planck Society and the research centre caesar, was taken over by FEI Company on a share deal basis. Thus the phase contrast technology developed by KonTEM is absorbed in the portfolio of a globally operating market leader in the field of high-performance microscopy workflow solutions.

Researcher at the LDC (© LDC)

The Lead Discovery Center GmbH (LDC), a renowned translational research organization, and Daiichi Sankyo Co., Ltd. (hereafter, Daiichi Sankyo), Japan, have teamed up to discover new medicines for the treatment of disease with high unmet medical needs. The partners will focus on targeted disease areas and novel mechanisms of strategic interest to Daiichi Sankyo, including oncology, cardiovascular and metabolic diseases.

© Bodylabs

Body Labs, Inc., a company based in New York City, has developed the world's most advanced technology for creating 3D digital avatars in a fully automated way. The technology, based on nearly a decade of research from Brown University and the Max Planck Institute for Intelligent Systems, makes it possible to easily create highly accurate and realistic avatars that can mimic the entire range of human motion. This capability opens up new possibilities for clothing and product design, 3D printing for specialty equipment and apparel, gaming, animation and online apparel sales.

Image: If Parkinson's mice received the active ingredient anle138b, significantly fewer synuclein deposits (colored brown) formed than in placebo-treated control animals. (Photo: Giese, LMU Munich)

Neurodegenerative diseases are diseases of the nervous system that often progress slowly and are characterized by a loss of mental and physical abilities. The deposition of disease-relevant accumulations of protein in the brain plays an important role in the pathogenesis of many neurodegenerative diseases. Scientists at the Ludwig-Maximilians-Universität München (LMU) and the Max Planck Institute (MPI) for Biophysical Chemistry in Göttingen have successfully developed a drug candidate that can significantly reduce the formation of these deposits. In the joint spin-off company MODAG GmbH the active substance anle138b is now to be developed up to market maturity to stop diseases such Parkinson’s, Alzheimer’s and Creutzfeld-Jakob in the future. To this effect, MODAG successfully concluded its first round of financing with up to EUR 8 million in participation with the Bayerische Patentallianz GmbH representing the two research institutions LMU and Max Planck Society (MPG).


© Gorodenkoff - Fotolia

The Lead Discovery Center GmbH (LDC) announces today that an innovative kinase inhibitor program licensed to Bayer Pharma AG, Germany (Bayer) in 2011, has been progressed to clinical trials. By 2012, Bayer had successfully advanced a lead compound from the program to the preclinical development stage. This fall, Bayer enrolled the first participant into a Phase I study to determine the safety, tolerability and pharmacokinetic profile in patients with advanced cancer.


© Gorodenkoff - Fotolia

Lead Discovery Center GmbH (LDC) a renowned translational research organization, today announced a five-year strategic partnership with Merck Serono, Darmstadt, Germany, the biopharmaceutical division of Merck. This collaboration integrates the expertise and resources of both organizations to expedite the discovery of promising lead structures and to optimize the development of therapeutic candidates in areas of high unmet medical need.

© Patrick Daxenbichler - Fotolia

Dolby Laboratories, a world leader in audio and imaging technologies, has licensed an innovative imaging patent portfolio from the Max Planck Institute for Informatics – The technology relates to High Dynamic Range (HDR) imaging and increases the ability of images to show real world light intensities and color levels, while also reducing storage requirements. The technology provides an innovative design which makes it possible to achieve high picture quality from HDR-capable displays, while also providing backward compatibility with existing low-dynamic range (LDR) displays. Dolby is now aiming to develop the technology for use with next generation displays.


The picture shows bacteria of the attenuated tuberculosis vaccine strain (BCG) inside a macrophage, a scavenger cell of the immune system. Courtesy: MPI for Infection Biology - CF Microscopy / Volker Brinkmann

Hopes are high for a new and improved tuberculosis vaccine: Serum Institute of India is planning on taking a promising vaccine - originally developed in Germany - and introducing it into the clinical setting. Studies have shown that the new vaccine is more effective and better tolerated than currently available options. By signing a contract with the Hannover-based Vakzine Projekt Management GmbH (VPM), Serum, one of the World’s leading vaccine manufacturers, has effectively secured the license to the various patents and technologies related to the new vaccine.

© Max-Planck-Gesellschaft

STED microscopy creates high-resolution images far below the diffraction limit of visible light. However, the technique’s engineering aspects remain comparatively complex, which impedes its dissemination and use. A technology called EASYDOnut, developed by the Max Planck Institute for Biophysical Chemistry and the German Cancer Research Center, simplifies the optical system considerably and has now been licenced by spin-off Abberior GmbH. EASYDOnut precisely guides the laser beams of the STED microscope onto the sample being investigated by means of a single optical element. This innovation can encourage the spread of STED microscopy and benefit medical research. STED microscopy permits significant information to be obtained, even from living human cells.


© kaninstudio - Fotolia

The Max Planck Institute of Biochemistry (MPIB), the Lead Discovery Center GmbH (LDC) and Qurient Co., Ltd have entered into a license agreement providing Qurient with world-wide, exclusive rights to a new kinase inhibitor for the treatment of metastatic cancer.

© totojang1977 - Fotolia

The Lead Discovery Center GmbH (LDC) and AstraZeneca have joined forces to discover new medicines for the treatment of human diseases with high unmet medical need. Through a two-year collaboration, AstraZeneca will add 250,000 high-quality compounds to LDC’s internal screening collection to pursue projects in the areas of oncology, neuroscience, respiratory and inflammation, cardiovascular, gastrointestinal and infection research.


© Carmen Steiner - Fotolia

The Hennigsdorf firm Drug Response Dx GmbH (DRDx GmbH) successfully concluded its first round of financing with High-Tech Gründerfonds and QIAGEN. The investment will serve to develop a biomarker test kit for rheumatoid arthritis treatment guidance with so-called TNF-alpha inhibitors. The test is secured by a unique patent platform exclusively in-licensed by the Max Planck Society (MPG).


© tycoon101 - Fotolia

Joint Press Release of the German Center for Neurodegenerative Diseases and the Max Planck Research Unit for Enzymology of Protein Folding

© ashtproductions - Fotolia

The Lead Discovery Center GmbH (LDC) announces today that an innovative kinase inhibitor program licensed to Bayer Pharma AG, Germany (Bayer) last year, has reached an important transition milestone. Bayer has successfully advanced this kinase inhibitor program into pre-clinical development with the goal of eventually advancing this candidate into oncology clinical development. Protein kinases are key components of cellular signaling pathways that control tumor cell growth, metabolism and metastasis. They have therefore become prime targets for oncology drug discovery and clinical development.

© waranyu - Fotolia

Max Planck Innovation, the technology transfer organization of the Max Planck Society together with the Patent Marketing Agency of Saarland Universities have licensed a new method for processing digital stereo image content to TandemLaunch Technologies, a Canada based company, which develops multimedia inventions into consumer technologies. The new “Backward-compatible Stereo 3D” technology makes it possible to watch movies in 3D, when wearing glasses, and 2D without glasses at the same time.

Prof. Dr. Hans Schöler (© MPI Münster / J. Müller-Keuker)

Professor Hans Schöler, Director of the Max Planck Institute (MPI) for Molecular Biomedicine in Münster, welcomes the clear commitment to CARE made by the state government of North-Rhine Westphalia: “We are delighted to report that a firm agreement has been reached on the development of this important institute.” The proposed translational research centre will jointly further develop insights from basic research together with the business community so that they can provide a real benefit for patients in the form of new treatment and diagnostic processes. CARE was initiated by the MPI in Münster and Max Planck Innovation, the Max Planck Society’s technology transfer organisation.


© Romario Ien - Fotolia

Life Science Inkubator promotes new research team --- Scientists from the Life Science Inkubator (LSI) in Bonn, which was established by the technology transfer organisation Max Planck Innovation with the aim of facilitating spin-offs in the field of the life sciences, want to explore new directions in the area of pain therapy. The aim is to suppress pain using weak electric and mechanical stimuli. The stimulation will be generated using special bandages with integrated high-tech chips. Preliminary studies indicate that this process is particularly suited to the alleviation of chronic pain.

© Kzenon - Fotolia

Joint press release of High-Tech Gründerfonds, Max-Planck-Innovation GmbH, Center of advanced european studies and research (caesar) and KonTEM GmbH --- KonTEM GmbH, a spin-off company of the Max-Planck-Gesellschaft (MPG) and the Center of advanced european studies and research (caesar), has developed an innovative phase contrast system for transmission electron microscopes (TEM). The system combines enhanced image contrast with high object resolution and thus opens up new possibilities for the analysis of biological specimen. With its investment, the High-Tech Gründerfonds (HTGF) supports the operational ramp-up and growth of the young company and emphasizes the high potential of this innovative technology.