Tuberculosis vaccine passes safety test
The vaccine candidate VPM1002 shows its safety in a study with HIV- and non-HIV-exposed newborns
At least 20 million people worldwide suffer from tuberculosis, according to World Health Organization (WHO), with 10 million new cases every year and about 1.5 million deaths annually. The disease is caused by mycobacteria, which predominantly affect the lungs, but can also infect any other organ. Tuberculosis is particularly common in low income countries. Here, the WHO recommends that newborns be immunized against it as soon as possible.
First used 100 years ago, the BCG vaccine against the disease contains attenuated pathogens of cattle tuberculosis. “We know that BCG can prevent so-called tuberculous meningitis and miliary tuberculosis in infants with a 75 to 86 percent effectiveness rate. But this is not the case for the most common form of the disease, pulmonary tuberculosis, in all age groups. Here, BCG is only insufficiently effective,” explains Kaufmann, Emeritus Director at the Max Planck Institute for Multidisciplinary Sciences in Göttingen and the Max Planck Institute for Infection Biology in Berlin.
Since the 1990s, the infection biologist and his team have been working on an improved next-generation vaccine, called VPM1002. To achieve this, the researchers genetically modified the attenuated BCG vaccine strain so that immune cells can better recognize the pathogens. “We developed VPM1002 in no small part to combine increased safety with improved efficacy for immunocompromised children,” the Max Planck researcher reports.
Vaccine candidate VPM1002 is safe
The group of immunocompromised children includes, for example, HIV-exposed infants born to HIV-positive mothers. In a clinical trial in South Africa, an international research consortium including Kaufmann has now compared VPM1002 with BCG in HIV-exposed and non-HIV-exposed newborns. The study examined both the safety and the immune response induced – called immunogenicity – associated with the formation of immune cells and immunostimulatory proteins. The conclusion of the study: VPM1002 is safe in both HIV-exposed and non-HIV-exposed newborns, has fewer side effects than BCG, and elicits a similar immune response.
In the randomized phase II double-blind study in South Africa, 416 eligible newborns were randomly selected and vaccinated before day 12 of life. 312 of them received VPM1002, and 104 received the BCG vaccine. As the study showed, VPM1002 triggered fewer vaccine-related adverse reactions than BCG. This was true for reactions occurring at the injection site, such as scarring and abscess formation, as well as enlargement of lymph nodes. This finding is important because local and regional reactions after vaccination are among the limitations of the BCG vaccine, Kaufmann points out.
Newborns with or without HIV exposure showed similar immunogenicity with both vaccines. However, starting at six weeks of age, the BCG-triggered immune response was greater than in even younger infants.
Phase III study investigates protection
“Studies such as those described here examine a vaccine’s immunogenicity, but not its protection. For the latter, we have already developed a larger phase III clinical trial and have successfully enrolled mothers with their newborns to participate. Now the clock is ticking,” Kaufmann said. The infectious biologist expects initial results showing whether VPM1002 can provide comparable or better protection than existing BCG vaccines in about three years. In addition, the VPM1002 vaccine is currently evaluated in adults in two other phase III clinical trials in India for protection against tuberculosis. These trials are expected to be completed in 2023 and 2024, respectively.
The Max Planck Society licensed the VPM1002 vaccine to the company Vakzine Projekt Management (VPM) in 2004. Starting in 2012, the company continued to develop the vaccine in collaboration with the Serum Institute of India, one of the world’s largest vaccine manufacturers. “Serum Institute of India is giving access to a unique solution for tuberculosis elimination by detect-treat-prevent strategy. VPM1002 is a unique component of this strategy, and it will help in preventing infection and disease. The ongoing phase III trial is one of the key trials in order to strengthen our scientific rationale. Pleased to see that we have completed recruitment of all infants in such an important trial,” said Umesh Shaligram, Executive Director R&D of Serum Institute of India.
Institutions involved in the study
The study is an international collaboration between Serum Institute of India, Pune (India), Tygerberg Academic Hospital, Parow Valley (South Africa), South African Medical Research Council, Department of Science / National Research Foundation (South Africa), University of the Witwatersrand, Johannesburg (South Africa), South African Tuberculosis Vaccine Initiative (SATVI), the University of Cape Town (South Africa), the Desmond Tutu TB Centre, Cape Town (South Africa), Stellenbosch University (South Africa), EMMES Services Private Limited, Bengaluru (India), HJ Clinical Trial Consultancy, George (South Africa), Vakzine Projekt Management GmbH, Hannover (Germany), as well as Texas A&M University (US) and the MPIs for Infection Biology, Berlin (Germany) and for Multidisciplinary Sciences (until 1.1.2022: MPI for Biophysical Chemistry), Göttingen (Germany).
About Vakzine Projekt Management GmbH (VPM)
Founded originally in August 2002, VPM was established following an initiative of the German Federal Ministry of Education and Research (BMBF) to promote the development of vaccines in Germany. Scope of the vaccine initiative was the funding of rapid transfer of results from basic research into the development of new vaccines. The BMBF provided VPM with 25.6 million euros funding between 2001 and 2010 to organize and finance the preclinical and clinical development of vaccines nationwide. To this end, VPM acquired proprietary rights to promising vaccine candidates from public German laboratories and managed their development until further licensing to industrial partners. In order to identify such promising vaccine candidates in Germany, a map of vaccine research with the associated technologies for research and development of vaccines was drawn up at the beginning of the BMBF funding and updated in 2006.
About the Max Planck Institute for Infection Biology
Infections are among the most significant medical challenges. The relationships between microbes and their hosts are also essential drivers of evolution. At the Max Planck Institute for Infection Biology, researchers from different disciplines search for answers to fundamental questions in infection biology. The scientists investigate how viruses, bacteria, parasites, fungi and worms cause diseases and how their hosts react to them. The research encompasses different levels: Atoms, molecules, cells, tissues and organisms as well as medical and social aspects.
About the Max Planck Institute for Multidisciplinary Sciences
The Max Planck Institute for Multidisciplinary Sciences was founded on 1 January 2022 through the merger of two existing Göttingen institutes, the MPI for Biophysical Chemistry and the MPI for Experimental Medicine. The two locations of the institutes remained as City Campus and Faßberg Campus. At the Institute, we explore scientific issues ranging from physics and chemistry to structural and cell biology, neuroscience and biomedical research. Basic research in the natural sciences can thus be linked even more effectively with medical research approaches. We are guided by the conviction that great scientific discoveries can be achieved when scientists from different disciplines and research cultures - such as physics, chemistry and biology - work together and exchange ideas in an unbiased way.
About Max Planck Innovation
As the technology transfer organization of the Max Planck Society, Max Planck Innovation is the link between industry and basic research. With our interdisciplinary team, we advise and support scientists at the Max Planck Institutes in evaluating inventions, filing patents and starting businesses. We offer industry central access to the innovations of the Max Planck Institutes. We are therefore fulfilling an important task: The transfer of results from basic research into commercially and socially useful products.
Further information can be found at www.max-planck-innovation.com
Diplom-Kaufmann, certified graphic designer
Phone: +49 89 / 29 09 19-30