Technology Offers
4'-Rhodamin Derivates as Fluorescent Dyes
Ref.-No.: 0104-5931-BC
Imaging and Microscopy
New Materials

"As a result of the evermore-enhanced super resolution microscopic techniques that allow observation of biological processes up to the molecular level in living cells the demand for fluorescent dyes owning the capability of specific binding to molecules like proteins as label for visualization aspects is increased.
A new class of rhodamine derivates that meets all requirements for the use in such biological environment could be developed in the group of Prof. Stefan Hell, Max Planck Institute ...
A graphene diode with bias-induced barrier modulation
Ref.-No.: 1201-5155-BC-JK
Sensors, Devices and Components

Metal-insulator-metal (MIM) diodes are very promising for application as rectennas for solar energy harvesting, photo-detectors and high frequency mixers. Good MIM diode performance requires a high asymmetry, a strong nonlinearity, a large responsively, as well as a low resistance or a high on-current. These figures of merit are mainly determined by the work function difference of the electrodes, and the barrier height between the insulator and the electrode materials. In the design of MIM diodes, ...
Read more … A graphene diode with bias-induced barrier modulation
A high-throughput compatible workflow for generation and analysis of homogenous human neural microtissues
Ref.-Nr.: 1012-5677-LI
Processes and Methods (incl. Screening)
File no.: MI-1012-5677-LI-ZE
(liked to MI-1012-4430-LI-ZE describing the generation of neuro- epithelial stem cells as precursors for microtissue generation)
A robust method for producing and analyzing highly homogenous human neural organoids.
A method and device for reversibly attaching a phase changing metal to an object
Ref.-Nr.: 0104-5132-BC
Sensors, Devices and Components

Reversible adhesion can be used to transfer or to manipulate objects. Especially if the objects are small and/or fragile their manipulation become very challenging. Intermolecular forces such as Van-der-Waals can be used to achieve a strong adhesion between the objects. Moreover, surface functionalization and the creation of nano- and microstructures can be used to improve these adhesion properties. Unfortunately, the adhesion becomes insufficient if the surfaces are wet or rough. Another problems ...
Read more … A method and device for reversibly attaching a phase changing metal to an object
A new VACCINE type able to induce STERILIZING IMMUNITY against epidemic threats caused by viruses such as SARS-CoV-2 (COVID-19) or other respiratory pathogens
Ref.-No.: 0204-3324-IKF
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine : Vaccines

"Novel first-in-class intra-nasally applicable safe recombinant "vir4vac" RNA vaccines constitute a very safe and efficacious way of preventing serious infections of respiratory corona and paramyxoviruses as well as other respiratory viruses.“
A novel biomarker for a reliable diagnosis of colorectal cancer based on differentially methylated genomic regions
Ref.-Nr.: 0301-4550-LI
Medicine : Diagnostics
With approximately 600,000 deaths annually colorectal cancer (CRC) is one of the most common cancer types worldwide. Early cancer and pre-cancer (polyps) detection by colonoscopy over the age of 50 until now is the best strategy for disease control and the chance of the cancer to be curable. Epigenetic changes such as DNA methylation has been shown to occur already at early stages of tumor development making such differentially methylated regions (DMRs) highly attractive for biomarker development ...
A novel class of herbal compounds saiginols with strong UV-B absorbing properties
Ref.-No.: 0402-4816-MG
Green Biotech
UV-B radiation is a major damaging agent causing damage to plants, tissues and human or animal skin upon exposure. To persist strong UV-B radiation plants produce additional antioxidant sunscreen pigments that belong to the chemical compound family of phenylpropanoids. Since many conventional compounds with sunscreen protection potential do not enter the market due to toxic side effects or they bear the risk to become environmental pollutants when accumulating in natural resources, application ...
Read more … A novel class of herbal compounds saiginols with strong UV-B absorbing properties
A novel inhibitor targeting matrix accumulation in cancer
Ref.-No.: 0105-5855_1-IKF
Medicine : Therapeutics
Medicine : Animal Models
Nucleic Acid-, Protein and Cell-related Technologies

Cancer remains a major health burden and is the second leading cause of death globally (WHO). The microenvironment of cancer cells plays an important role in disease progression. In particular, the composition of the extracellular matrix regulates angiogenesis, cell proliferation, differentiation, cell survival and apoptosis. Dysregulation and accumulation of the extracellular matrix promotes cellular transformation and metastasis leading to cancer progression. A better understanding of the role ...
Read more … A novel inhibitor targeting matrix accumulation in cancer
A novel inhibitor targeting matrix accumulation in fibrosis
Ref.-No.: 0105-5855_2-IKF
Medicine : Therapeutics
Medicine : Animal Models
Nucleic Acid-, Protein and Cell-related Technologies

Fibrosis is the excessive accumulation of extracellular matrix that leads to destruction of the tissue architecture and consequently organ failure. In the developed world, an estimated 45 % of all deaths resulted from severe fibrotic diseases. A wide range of chronic diseases are able to induce fibrosis such as hepatitis, pulmonary disease, scleroderma and cancer. Current therapies for fibrosis are limited and of low efficacy. Further research on fibrosis is required to understand disease progression ...
Read more … A novel inhibitor targeting matrix accumulation in fibrosis
A novel strategy for reducing inflammation by modulating immune cell metabolism
Ref.-Nr.: 0106-5185-MG
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine : Therapeutics
Nucleic Acid-, Protein and Cell-related Technologies : Cell related

Remodeling the morphology of mitochondria to manipulate immune cell metabolism and hence reduce immune cell activation and effector functions
Read more … A novel strategy for reducing inflammation by modulating immune cell metabolism
A novel type of influenza A virus-derived Defective interfering Particle for antiviral therapy
Ref.-Nr.: 1402-5459-BC
Research Tools : Antibodies

Human influenza A virus (IAV) is responsible for seasonal disease in people and can cause worldwide pandemics. The main lines of defense against IAV are vaccines and antiviral drugs.
Influenza vaccines, including killed and live vaccines, recombinant virus-like particles and viral particles, have been available commercially for many years. Typically, the composition of influenza vaccines is based on the major influenza virus strains causing infection in the previous season. Accordingly, ...
A system-wide approach for the identification of druggable proteins in a complex mixture
Ref.-Nr.: 0402-5163-MG
Analytics
In contrast to target-based drug discovery, phenotypic screening discloses the effect of a compound on a biological system without revealing its mode of action or its interaction sites. Phenotypic screening has delivered several new valuable drugs, however, the major challenge remains target deconvolution (1). In recent years, “omics” techniques and bioinformatics have brought significant advances to target identification in drug discovery phenotypic screening. However, such analyses can become ...
Read more … A system-wide approach for the identification of druggable proteins in a complex mixture
A tunable cohesive granular material
Ref.-No.: 0705-5158-BC
New Materials

For sieving and separation purposes porous materials with adjustable sizes and shapes of the pores as well as tunable mechanical properties are required. The existing materials such as sintered materials, open-cell foams or cemented aggregates can be made porous but they are either fragile or can collapse for large deformation. Therefore, chemically inert and damage resistant porous materials with adjustable permeability as well as mechanical and geometrical properties that can sustain large deformation ...
Accurate contactless measurement of surface and micro sample temperatures
Ref.-Nr.: 0041-5601-WT
Sensors, Devices and Components

The study of mechanical properties of materials at high temperatures at the microstructural length scale requires dedicated testing setups. An accurate measurement of the sample temperature is vital for reliable testing. Most of the successful current testing platforms record the temperatures of the sample and tip near the heating sources but not at the respective surface. As a consequence, due to spatial and temporal thermal gradients a reliable surface temperature cannot be measured today. Even ...
Read more … Accurate contactless measurement of surface and micro sample temperatures
Advanced collector sweeping with homogenous power deposition of the electron beam in high-power rf vacuum-tubes
Ref.-No.: 1801-3749-WT
Sensors, Devices and Components
This invention includes two alternative advanced methods to achieve a homogenous collector power distribution, which improves the collector capability of high power vacuum-tubes by a factor of two as compared to conventional methods. Furthermore the applied method has a high flexibility to vary the power distribution over a wide range of profiles and match the deposition profiles to different designs of collectors in existing or future electron tubes.
Advanced magnetic zipper for industrial and consumer applications
Ref.-Nr.: 0705-4974-BC
Sensors, Devices and Components

Conventional mechanical zippers find manifold applications for luggage, clothing or even industrial applications. However, their design features significant disadvantages. In particular, they require the use of both hands by the user to align the ends of the garment and lock the insertion pin into the slider. This mechanism can be prone to jamming and failure and more generally requires the user to free his or her hands. The user must further use one or both hands to move the slider along the ...
Read more … Advanced magnetic zipper for industrial and consumer applications
Advanced vorticity measurements on complex flows
Ref.-Nr.: 0705-4770-BC
Sensors, Devices and Components

The dynamics of complex flows and turbulences are dominated by vortices of many different scales. In general, the vortex describes the group motion of fluid elements in a circular fashion, whereas the vorticity quantizes this spinning moment of a fluid element confined to a small neighborhood.
For diagnosis of flows, conventional techniques track the movements of small particles added into the flow (e.g., Lagrangian particle tracking, LPT, and particle image velocimetry, PIV). However, ...
Read more … Advanced vorticity measurements on complex flows
Air-stable binary Ni(0)–olefin (pre)catalyst
Ref.-Nro: 0042-5881-LC
Processes and Methods (incl. Screening) : Chemical
New Materials

A family of 16-electron binary Ni(0)-stilbene complexes Ni(Rstb)3 as a new class of air-stable Ni(0) (pre)catalysts was developed.
Alpha-defensins (HNPs) Effectively Inhibit Anthrax-related Toxemia
Ref.-Nr.: 0305-3252-LI
Medicine : Therapeutics

Anthrax is an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis. B.anthracis can cause human disease via the gastrointestinal, cutaneous or inhalational routes. There is still a considerably high rate of mortality from inhalational anthrax of up to 75 percent, even though fluorquinolone class antibiotics (e.g., ciprofloxacin) are being administered as a first-line therapy. This strategy, in addition, is being threatened by the spread of plasmid-mediated ...
Read more … Alpha-defensins (HNPs) Effectively Inhibit Anthrax-related Toxemia
Anti-mouse and anti-rabbit IgG secondary VHH single domain antibodies optimized for all immuno-labeling applications
Ref.: 0707-5419-LI
New Materials
Anti-IgG secondary antibodies are major tools for the detection or immobilization of primary antibodies in approaches such as western blotting, ELISA, Co-IP and immunofluorescence. Polyclonal anti-IgG secondary antibodies are produced in animals, such as mouse, rabbit, rat, and goat and are directed against the IgG classes of these animals. Thus, the generation of such secondary antibodies requires the keeping and use of a large number of animals, which is not only costly but also a major ethical ...
Apparatus and method for creating a holographic ultrasound field in an object
Ref.-Nr.: 0104-5066-BC
Sensors, Devices and Components

Ultrasound is being used in many fields ranging from medical imaging and therapy to non-destructive testing, contact-free particle handling or spatially selective heating in industrial settings. Often, those applications require shaping (including focusing) of an ultrasonic field. Compared to existing transducers with fixed lenses or phased array transducers (PATs) the present invention allows much more sophisticated sound fields to be generated using much simpler and cheaper technology.
Read more … Apparatus and method for creating a holographic ultrasound field in an object
BALSAC: Build and Analyze Lattices, Surfaces, And Clusters
Ref.-Nr.: 0302-1508-LC
IT / Software / Bioinformatics

PC-based software to construct lattice sections and clusters/molecules with extended graphical display and analysis options.
Read more … BALSAC: Build and Analyze Lattices, Surfaces, And Clusters
Bioinspired Liquid-Superrepellent Fibrillar Dry Adhesives
Ref.-No.: 0104-5929-BC
New Materials

Since 2000 bioinspired fibrillar dry adhesives have been studied intensively culminating in commercial products already available on the market. Currently known fibrillar adhesives are fully wetted by oils, leading to significantly decreased adhesion and friction performance. Therefore, a high demand exists for reversible dry fibrillar adhesives that can repel oil-like liquids and adhere strongly to surfaces wetted by them.
To meet the aforementioned challenges, an extraordinary fibrillar ...
Read more … Bioinspired Liquid-Superrepellent Fibrillar Dry Adhesives
BiQ Analyzer Software for DNA Methylation Analysis, Visualization and Quality Control
Ref.-No.: 1200-3727 BC
Analytics

BiQ Analyzer is a software tool for easy visualization and quality control of DNA methylation data. With more than a thousand users worldwide, BiQ Analyzer has become a standard tool for processing DNA methylation data from bisulfite sequencing. BiQ Analyzer has been selected by ABI to be part of the Applied Biosystems Software Community Program.
Read more … BiQ Analyzer Software for DNA Methylation Analysis, Visualization and Quality Control
Borylated Pyrenes and Terrylenes as blue and green emitters
Ref.-No.: 0903-5692-LC
New Materials

Prof. Klaus Müllen an co-workers at the Max-Planck-Institute for Polymer Research developed a straightforward C-H borylation at the 2- and 2,7-positions of pyrene derivatives. The small neutral organic molecules show sharp fluorescence emission peeks between 400-550 nm and high photoluminiscense quantum yields.
Read more … Borylated Pyrenes and Terrylenes as blue and green emitters
Carbon-neutral and carbon-positive photorespiration bypass routes supporting higher photosynthetic rate and yield
Ref.-Nr. 0402-5003-MG
Green Biotech
Carbon fixation is arguably the most important biochemical processes on earth, supporting our biosphere by transforming inorganic carbon into organic matter and literally feeding all life forms. The reductive pentose phosphate cycle (rPP, also known as the Calvin–Benson–Bassham Cycle) is responsible for ≥95% of the carbon fixed in the biosphere. Although under a strong selective pressure for eons, this process displays major inefficiencies, some are due to the low catalytic rate and the ...
Cell-Penetrating Fluorescent Dyes with Secondary Alcohol Functionalities
Ref.-No.: 0707-5236-BC
Imaging and Microscopy
New Materials

Fluorescent dyes are widely used as indispensable markers in biology, optical microscopy, and analytical chemistry. The availability and the proper choice of the dye is a key factor to success of the entire labelling and imaging procedure. Due to superior brightness and photostability, synthetic dyes often represent an attractive alternative to fluorescent proteins.
Among the multitude of fluorophores reported so far, only rhodamines, carbopyronines, and silicon-rhodamines bearing a carboxyl ...
Read more … Cell-Penetrating Fluorescent Dyes with Secondary Alcohol Functionalities
CellNetAnalyzer: A Software Package for Analyzing Structure and Function of Cellular Networks
Ref.-No. 1402-3895-LC
IT / Software / Bioinformatics

CellNetAnalyzer (CNA) is a MATLAB toolbox providing various computational methods for analyzing structure and function of metabolic, signaling, and regulatory networks. For metabolic networks, CNA supports a variety of stoichiometric and constraint-based modeling techniques, including flux balance analysis (FBA), metabolic flux analysis, elementary-modes analysis, or computational strain design (e.g., minimal cut set analysis). Signal transduction and (gene) regulatory networks can be ...
Closure Device for Evaporator Cell of a Coating System
Ref.-Nr.: 1201-5136-BC
Sensors, Devices and Components

Evaporation cells for thin film deposition often operate under ultrahigh vacuum or special gas atmosphere, requiring long growth campaigns and short maintenance openings to preserve the best possible vacuum environment. The deposition leads to coating of the inner chamber walls, the removal of which is difficult and very time consuming. Growth control and interruptions during material deposition may require frequent operation of the closure device or shutter. The commonly used shutter (Fig. 1) ...
Read more … Closure Device for Evaporator Cell of a Coating System
Compact high-voltage vacuum feedthrough
Ref.-Nr.: 0302-4988-WT
Sensors, Devices and Components

Applying high voltages in vacuum applications requires feedthroughs, which electrically insulate the conductor from the vacuum chamber whilst being vacuum-tight. In high- and ultrahigh vacuum environments, the materials used need to be low in outgassing rates. The current technology for feedthroughs withstanding tens to hundreds of kilovolts relies on vacuum-tight ceramic to metal connections, which are heavy, fragile and prone to contamination. Commercially available feedthroughs are stand-alone ...
Coupling part
Ref.-Nr.: 0704-5610-BC
Medicine : Diagnostics
Sensors, Devices and Components

This novel screwless coupling, which can also be used as overload clutch, offers the possibility without additional tools to connect two rotatable elements even under extremely tight conditions, backlash-free and force fit with high precision. Due to their size, couplings known to date on the market are unsuitable for applications in the field of electronics, optics, metrology and precision engineering. Whereas thanks to the new technology, which was developed at the Max Planck Institute for Solar ...
Cyclopropenylylidene-Stabilized Phosphenium Cations and their Applications in Homogeneous Catalysis
0042-5177-LC-WA
New Materials
DECONV-Software
1401-4358-WT
IT / Software / Bioinformatics
Lock-in thermography (LIT) is a versatile and very sensitive tool to detect local heat sources in electronic components by 2d-images oft he sample. The DECONV program is a tool for converting these lock-in thermography images into local power density images or simulating LIT images by performing mathematical deconvolution or convolution and uses input image data in ASCII table form. Results are exported as ASCII tables or as bmp-files.
This software is a further development of an older ...
Detection of adhesion resistance in cells or lipid membranes by noise analysis
Ref.-Nr.: 0204-3316-WT
Sensors, Devices and Components

The function of brain tissue is based on the dynamics of numerous nerve cells and their synaptic interaction. Direct electrical interfacing of semiconductors and nerve cells is the physical basis for a systematic development of hybrid neuroelectronic devices, such as neurocomputers and neuroprostheses. Excited nerve cells and field-effect transistors are coupled by a dissipative mechanism: ionic current through the adherent cell membrane flows along the electrical resistance of a narrow layer ...
Read more … Detection of adhesion resistance in cells or lipid membranes by noise analysis
Do you need to shut down protein synthesis reversibly and in a cell-type specific manner?
Ref.-Nr.: 0602-5504-LI
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Research Tools : Other
Nucleic Acid-, Protein and Cell-related Technologies : Nucleic acid related
A precise and genetically encoded inhibitor for cell-type selective, inducible and reversible inhibition of protein synthesis
Dynamic control of three-dimensional light distributions through wavefront engineering: hardware and software system
Ref.-No.: 0202-5001-LI
Analytics
IT / Software / Bioinformatics

Engineering light distributions in a three-dimensional volume to achieve selective illumination profiles is an instrumental task shared by many optical and microscopy techniques. The optimization of the light distribution can lead to significant enhancement of relevant performance figures and ultimately to the extension of the instrument or experimental protocol capabilities1,2,3,4,5. Targeted illumination profiles can be used either to mechanically interact with molecules at nanometer ...
eeFILM – Extended Excitation for Faster Measurement of Fluorescent Lifetimes
Ref.-No.: 0707-5026-BC
Sensors, Devices and Components

The estimation of excitation lifetimes based on fluorescence or phosphorescence emission is an essential technique in basic and applied science. It provides information on molecular interactions
as well as on physical properties. Measuring the emission lifetime with spatial resolution provides an imaging modality, which in case of fluorescence is called Fluorescence Lifetime Imaging (FLIM). FLIM is applied extensively in biological imaging in order to determine the conformation, activation, ...
Read more … eeFILM – Extended Excitation for Faster Measurement of Fluorescent Lifetimes
Efficient cooling of commercially available electrical wiring by the use of metals with low melting temperatures
Ref.-No.: 1801-4852-WT
Sensors, Devices and Components

Resistance induced heating of electrical wiring during operation is one of the limiting factors to design high-power electromagnetic coils. The commonly used approach to eliminate the heating of electrical wires is to introduce a hollow conductive copper wire into electrical wiring and to cool this wire with water. Unfortunately, this approach is not applicable for high power density electromagnetic coil as well as for coils with small dimensions. Another approach to enhance the cooling properties ...
Electroluminescence Imaging Evaluation: Software EL-Fit
Ref.-No.: 1401-4175-WT
IT / Software / Bioinformatics
This software is based on the paper "Quantitative evaluation of electroluminescence images of solar cells" by O. Breitenstein et al.1). It allows to load a number of electroluminescence (EL) images to different biases, which have to be given as ASCii tables.
Read more … Electroluminescence Imaging Evaluation: Software EL-Fit
Enhancement resonator including non-spherical mirrors
Ref.-No.: 1202-4590-WT
Sensors, Devices and Components

An Enhancement Cavity (EC) with at least one toroidal and/or cylindrical mirror is described. This allows for an arbitrary beam ellipticity of the eigenmode. In particular at a stability edge, where the ellipticity diverges with purely spherical optics, a round beam can be obtained.
Read more … Enhancement resonator including non-spherical mirrors
Exergy Efficient Chlorine Separation
Ref.-No.: 1402-5465-LC
Processes and Methods (incl. Screening) : Chemical

Three novel processes to separate Cl2 from unconverted HCl in the anode outlet stream of a electrochemical gas-phase reactor were developed at the MPI for Dynamics of Complex Technical Systems. The novel processes lead to a higher reaction yield in gas-phase reactor and have an reduced energy demand compared to the Bayer UhDenora state-of-the-art process.
Fabrication of ultrathin nano-porous membranes and semiconductor nanowires (Kopie)
Ref-No.: 0104-4458-BC
Imaging and Microscopy
New Materials

Semiconductor nanowires are of vital importance for many applications, such as flexible electronics, photonics, sensors, and energy harvesting and storage devices. As standard fabrication procedure, vapor-liquid-solid (VLS) growth employs metal catalyst particles (such as gold) as seeds for growth of nanowires. The seeds are deposited on a solid substrate, melted by heating and then exposed to a gas atmosphere containing source materials of the semiconductor. When the metal droplets are supersaturated, ...
Read more … Fabrication of ultrathin nano-porous membranes and semiconductor nanowires (Kopie)
Fast and efficient protein purification form prokaryotic and eukaryotic hosts
Ref.-No.: 0109-4896-LI
Processes and Methods (incl. Screening)
Fusion Tags Comprising Ubiquitin-like Modifiers and Corresponding Proteases For Protein Purification From Selected Eukaryotic Expression Hosts
Read more … Fast and efficient protein purification form prokaryotic and eukaryotic hosts
FFA2 (GPR43) and FFA3 (GPR41) as novel targets for antidiabetic therapies
Ref.-No.: 0603-4987-IKF
Medicine : Therapeutics
Medicine : Animal Models
Nucleic Acid-, Protein and Cell-related Technologies : Protein related
A double KO, a conditional KO as well as single KO mouse models for FFA2 and FFA3 (free fatty acid receptors 2 and 3), novel targets for diabetes therapies.
Read more … FFA2 (GPR43) and FFA3 (GPR41) as novel targets for antidiabetic therapies
Flash 2 – Real-Time Magnetic Resonance Imaging (MRI)
Ref.-Nr.: 0707-4198-BC
Imaging and Microscopy
Sensors, Devices and Components

Magnetic resonance imaging (MRI) is nowadays a leading mo¬dality for diagnostic imaging with about 100 million examinations per year worldwide. However, when invented by Paul Christian Lauterbur in 1973, MRI was too slow to allow for routine medical applications. A breakthrough was achieved in 1985 by the FLASH (Fast Low Angle Shot) technique developed by Jens Frahm and his team at the Max-Planck-Institute for Biophysical Chemistry in Göttingen, Germany. With FLASH the measuring time for a cross-sectional ...
Read more … Flash 2 – Real-Time Magnetic Resonance Imaging (MRI)
Graphene Balls and electrochemical cells containing these materials
Ref.-No.: 0903-4524-LC
New Materials

We offer a new simple and low cost technology to fabricate graphene-encapsulated metal or metal compound nanoparticles. The resulting hybrid nanoparticles are protected by granted substance claims in US, CN, TW and EP (DE, FR, GB, BE). Currently the patent protected graphene coated nano particles are discussed as high performance electrode materials in the lithium ion battery business (for example Samsung's "Graphene Balls").
Read more … Graphene Balls and electrochemical cells containing these materials
High efficiency hydrodynamic collimation vacuum interface for atmospheric pressure ion sources
Ref.-No.: 1201-4433-BC
Sensors, Devices and Components

In mass spectroscopy, many ion sources that transform the specimen to be tested into gas phase ions operate at ambient or elevated pressure. The generated ions have to be transferred into vacuum for further characterization, for instance in a mass analyzer.
The ion transfer into vacuum represents a major bottleneck. Because the pumping power increases rapidly with the size of an opening, long capillaries or small pinholes have to be used. Their transmission is commonly as low as 1%, in optimal ...
High-precision base editors for site-specific single nucleotide conversion
Ref.-No.: 0402-5782-MG
Processes and Methods (incl. Screening)
The CRISPR-Cas system is a powerful tool for site-specific genome editing. It allows for the inactivation or substitution of entire genes. However, most hereditary diseases in humans are caused by single point mutations, the correction of which requires only subtle changes to the DNA. Recently, base editors (BEs) were developed that allow the introduction of selective nucleotide substitutions. A Cas9 enzyme is fused to a nucleobase deaminase catalysing C-to-T mutations (by C-to-U deamination) ...
Read more … High-precision base editors for site-specific single nucleotide conversion
Homogenous, TR-FRET-based method for measurement of RNA- and DNA-polymerase activity
Ref.-No.: 1013-4990-IKF
Analytics
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Nucleic Acid-, Protein and Cell-related Technologies : Protein related
Nucleic Acid-, Protein and Cell-related Technologies : Cell related

An innovative high throughput screening method for measurement of RNA- and DNA-polymerase activity at room temperature, based on time-resolved FRET.
Read more … Homogenous, TR-FRET-based method for measurement of RNA- and DNA-polymerase activity
Laser device with kerr effect based mode-locking and operation thereof
Ref.-Nr.: 1202-4422-WT
Sensors, Devices and Components

A laser device (100), configured for generating laser pulses, has a laser resonator (10) with a gain disk medium (11) and a Kerr medium (12). The laser resonator (10) includes a first mode shaping section (13) which is adapted for shaping a circulating electric field coupled into the gain disk medium (11), and a second mode shaping section (14), which is adapted for shaping the circulating electric field coupled into the Kerr medium (12) independently of the electric field shaping in the first ...
Read more … Laser device with kerr effect based mode-locking and operation thereof
Leaf metabolites as markers for mycorrhizal colonization of plant roots
Ref.-Nr.: 1602-5392-LI
Green Biotech

Screening the level of specific blumenols in plant leaves allows simple implementation in marker assisted breeding and high-throughput analysis.
Read more … Leaf metabolites as markers for mycorrhizal colonization of plant roots
LITESEC - Light-controlled protein delivery into eukaryotic cells with high spatial and temporal resolution
Ref.-No.: 0706-5707-IKF
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine : Drug delivery
Nucleic Acid-, Protein and Cell-related Technologies : Protein related

The LITESEC-T3SS (Light-induced translocation of effectors through sequestration of endogenous components of the T3SS) system represents a novel, fast, specific, and reversible method to control protein secretion into eukaryotic cells, enabling various medicinal and biotechnological applications, such as targeted drug delivery for tumor therapy.
Lock-in thermography evaluation software for solar cells – Local I-V 2 (replacing Local I-V)
Ref.-No.: 1401-4359-WT
IT / Software / Bioinformatics
The efficiency of solar cells is strongly affected by local inhomogeneities. Especially inhomogeneities of the dark-current voltage (I-V) characteristic are of interest: The local dark current-voltage characteristic is a measure for the local recombination properties of the solar cell. Lock-in thermography performed in the dark (DLIT) can be used to detect and evaluate locally increased dark current densities.
MARS – software for robust and automatic backbone assignment of protein NMR spectra
Ref.-No.: 0707-5990-MG
Analytics
IT / Software / Bioinformatics : (other) Software
Nucleic Acid-, Protein and Cell-related Technologies : Protein related
MARS is a powerful program for robust automatic backbone assignment of proteins. MARS is applicable to proteins with extreme chemical shift degeneracy such as high molecular weight proteins and partially disordered or fully intrinsically disordered proteins. MARS is successfully used in many labs world-wide as evidenced by a huge number of citations.
Read more … MARS – software for robust and automatic backbone assignment of protein NMR spectra
Method and radiation source for generating pulsed coherent radiation
Ref.-No.: 1302-3482-WT
Sensors, Devices and Components
The present invention relates to a method of generating pulsed coherent radiation in the UV and XUV wavelength ranges. Furthermore, the present invention relates to a radiation source for generating pulsed coherent radiation based on a high harmonic generation (HHG).
Read more … Method and radiation source for generating pulsed coherent radiation
Method for the Calibration of a Microscope Setup
Ref.-No.: 1201-5661-BC
Imaging and Microscopy

Errors in super-resolution microscopy (SRM) can be identified with pairs of emitters that have fixed and precisely known relative positions. Such reference and calibration structures are exceedingly rare on the nanoscale. Here, Nitrogen-vacancy centers in diamond (NVs) offer a formidable solution. These fluorescent defects are photo-stable and due to the excellent properties of their brilliant host, do not diffuse and are resilient against temperature or chemical environment changes.
On ...
Read more … Method for the Calibration of a Microscope Setup
Mouse model for mitochondrial diseases
Ref.-No.: 1013-4827-IKF
Medicine : Animal Models
Research Tools
A tRNAALA heteroplasmy mouse model to study mitochondrial disorders such as encephalomyophathies, that recapitulates symptoms as observed in human patients with disease-causing mutation in the same mitochondrial gene.
Multichannel coil for UHF MRI
Ref.-No.: 0107-4677-BC
Imaging and Microscopy
Sensors, Devices and Components

Exploiting the benefits offered by magnetic resonance imaging (MRI) at ultra-high fields (≥ 7 Tesla) requires optimized radiofrequency (RF) coils. MRI at UHF operates in a regime where the RF wavelength is comparable to the dimensions of the sample size, resulting in an inhomogeneous distribution of the transmit field (B1+) and in an impaired image quality. An array of independent transmit coils arranged in multiple rows provides the degrees of freedom to influence the ...
Multifunctional RFID-based Platform for Animal Observation and Manipulation
Ref.-No.: 0214-5247-MG und 0214-5440-MG
IT / Software / Bioinformatics : (other) Software
Sensors, Devices and Components : Sensors
Sensors, Devices and Components : Devices
Sensors, Devices and Components : Components

An efficient system to monitor and control animal behavior in wildlife as well as in laboratory settings
Read more … Multifunctional RFID-based Platform for Animal Observation and Manipulation
N-substituted pyridiniophosphines, processes for their preparation and their use
Ref.-Nr.: 0042-4938-LC-WA
Processes and Methods (incl. Screening) : Chemical
Research Tools : Other
New Materials
We offer a new family of cationic ligands, namely N-alkyl/aryl pyridiniophosphines. The ligands can be synthesized through a short, scalable, and highly modular route.
Evaluation of their electronic properties evidenced weak σ-donor and quite strong π-acceptor character when used as ancillary ligands.
Read more … N-substituted pyridiniophosphines, processes for their preparation and their use
Nanographene-based dyes as high performance probes for super-resolution microscopy
Ref.-Nos.: 0903-5658-LC; 0903-5696-LC
Analytics
Imaging and Microscopy
New Materials

A group of scientists at the MPI for Polymer Research in Mainz developed nano-graphene structures that can be used as a new class of fluorophores for super-resolution microscopy (SMLM and STED).
They perform like hybrids of organic dyes and QDs: they have excellent environment-independent blinking properties, emit high photon numbers, display high photo-stability, possess low toxicity, have a molecular size below 2 nm, and have narrow excitation and emission spectra.
These nanographene ...
Read more … Nanographene-based dyes as high performance probes for super-resolution microscopy
Neuro-epithelial stem cells (NESC) capable of forming both central nervous system (CNS) and peripheral nervous system (PNS) neurons
Ref.-Nr.: 1012-4430-LI
Processes and Methods (incl. Screening)
File no.: MI-1012-4430-LI-ZE
(liked to MI-1012-5677-LI-ZE describing the generation of human neural microtissues from NECS cells)
A novel precursor population that forms electrophysiologically functional neurons more quickly than protocols starting with hPSCs.
New cell type promoting osteogenesis in bone
Ref.-No.: 1012-4727-IKF
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine
Nucleic Acid-, Protein and Cell-related Technologies : Cell related
A method to reprogram bone endothelial cells into cells that are able to mediate bone angiogenesis and osteogenesis, opening new avenues to treat osteoporosis.
New KDAC assay and selection system
Ref.-Nr.: 0803-5480-IKF
Analytics
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine : Diagnostics
Nucleic Acid-, Protein and Cell-related Technologies : Protein related

Extremely sensitive, reliable and fast novel KDAC assay, which can be performed in a continuous format. This novel KDAC assay is based on Firefly luciferase harboring an acetylation on an essential active site lysine, incorporated by genetic code expansion. We furthermore offer a bacterial selection system for KDACs, which uses a reporter enzyme inactivated by lysine modifications at an essential active site residue, thereby linking deacetylase activity to a selectable output.
Novel antiviral therapy against HIV-1 and alphaviruses: reducing frameshifting by increasing tRNALeu concentrations
Ref.-Nr.: 0707-5639-MG
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine : Therapeutics
Nucleic Acid-, Protein and Cell-related Technologies : Nucleic acid related

Antiviral therapy against retroviruses and alphaviruses using tRNALeu(UUA) overexpression
Novel Biomarkers for Ageing and Metabolic Health
Ref.-Nr.: 1013-5354-IKF
Analytics
Medicine : Therapeutics
Medicine : Diagnostics
Research Tools : Other
Nucleic Acid-, Protein and Cell-related Technologies : Cell related

Biomarkers of ageing have long been sought after to help assess the biological age and general health status of individuals. Considerable efforts have been invested to identify such biomarkers, including physiologic readouts, metabolic parameters, glycomic profiles and others. Nevertheless, markers with strong predictive power have remained elusive.
Work in model organisms has identified several conserved signaling pathways that extend life span, such as reduced insulin/IGF signaling and ...
Read more … Novel Biomarkers for Ageing and Metabolic Health
Novel glycan markers for diagnosis and vaccine against toxoplasmosis
Ref.-Nr.: 0401-4561-MG
Medicine : Diagnostics
Synthetic Glycosylphosphatidylinositols (GPIs) with high selectivity and purity for Toxoplasmosis diagnosis and vaccine.
Read more … Novel glycan markers for diagnosis and vaccine against toxoplasmosis
Novel Lignin Nanocarriers for Smart Drug Delivery in Crop Protection
Ref.-No.: 0903-4955-LC
Green Biotech

The Max Planck Institute for Polymer Research in collaboration with the Institute of Biotechnology and Drug Research (IBWF) developed novel lignin nanocarriers that can be used for smart pesticide delivery in plants for crop protection. The nanocarriers are characterised by a narrow size distribution and an easy manufacturing, furthermore, they can be loaded with hydrophobic pesticides. Injected to plants, the nanocarriers act as a safe store of pesticide, which is released in situ by lignin degrading ...
Read more … Novel Lignin Nanocarriers for Smart Drug Delivery in Crop Protection
Novel method for analysis of complex carbohydrate structures by ion-mobility mass spectrometry (IM-MS)
Ref.-Nr.: 0401-5070-MG
Analytics
Carbohydrates form one of the major classes of biological macromolecules in living organisms, but structural analysis and the quality control of carbohydrate structures represent a major challenge due to the frequent occurrence of isomers that are difficult to distinguish using established techniques.
Changes in protein glycosylation are frequently identified in the context of diseases. For example, alterations in N-glycan profiles from blood plasma have been found to correlate with pathological ...
Novel protein expression optimization method combining machine learning with insights from mechanistic modelling of mRNA translatio
Ref.-Nr.: 0401-5011-LC-WA
IT / Software / Bioinformatics : Bioinformatics

Researchers of the Max-Planck-Institute for Colloids and Interfaces and the Paul-Ehrlich-Institute (PEI) have developed a novel codon-specific elongation model (COSEM), that is based on the question how codon bias affects protein expression in combination with a deep understanding of protein synthesis.
Optimised Flow-Through-Cell for Online-Microscopy
Ref.-No.: 1402-5292-BC
New Materials

For the evaluation of crystallisation processes, process parameters like temperature and concentration can be easily measured. However, to measure the crystal size distribution continuously is a challenging task.
Different methods relaying on back scattering or reflection of monochromatic light can be applied that yield chord-length distributions, which often deviate from the actual crystal or particle size distribution. For analysing the true crystal dimensions and, additionally, the crystal ...
Read more … Optimised Flow-Through-Cell for Online-Microscopy
Ozone scrubber
Ref.-No.: 0901-5500-LC
Analytics
Processes and Methods (incl. Screening) : Chemical

Scientists in the group of Atmospheric Chemistry at the Max Planck Institute for Chemistry in Mainz have developed a novel thiosulfate based ozone scrubber to ensure accurate measurements of trace analytes. It is known from the literature that commercial potassium iodide (KI) containing ozone scrubbers can cause errors in the measurement of carbonyl compounds such as aldehydes and ketones due to byproducts formed from the oxidation of KI. Commercial ozone scrubbers based on sodium thiosulfate ...
Parallel-imaging time-of-flight momentum microscope
Ref.-No.: 1401-4572-WT
Imaging and Microscopy
Sensors, Devices and Components : Devices

The state of an electron is completely defined by its momentum and spin. In processes like electron diffraction or photoemission electron ensembles are generated which have a characteristic 3D distribution of momentum and spin. To examine such events the three components of the momentum vector have to be measured. Up to now, the momentum distribution of an ensemble of charged particles was typically measured using energy-dispersive spectrometers based on sequential approaches (sequentially changing ...
Read more … Parallel-imaging time-of-flight momentum microscope
PLAYFUL Reactive Programming for Orchestrating Robotic Behavior
Ref.-No.: 0104-5603-BC
IT / Software / Bioinformatics

Playful is a scripting language for orchestration of Python modules. Playful allows developers to both organize the logic of activation in reactive behaviour tree and setup sensory-motor couplings, making it especially useful for robotics
Read more … PLAYFUL Reactive Programming for Orchestrating Robotic Behavior
PONy Dyes – Fluorescent Dyes with Phosphorus Substituents
Ref.-No.: 0707-5297-BC
Imaging and Microscopy
New Materials

Fluorescent dyes are widely used as indispensable markers in biology, optical microscopy, and analytical chemistry. In particular, the sensitive and stable imaging of cellular components depends on the favourable combination of chemical, biological and physical factors. The availability and proper choice of fluorescent dyes is a key factor to success in the entire labelling and imaging procedure. Due to their superior brightness and photostability, synthetic dyes represent an attractive alternative ...
Read more … PONy Dyes – Fluorescent Dyes with Phosphorus Substituents
Predicting Concentrations, Reactions Rates and Rate Constants in Biochemical Networks
Ref.-No.: 0402-5469-MG
Analytics
IT / Software / Bioinformatics : Bioinformatics
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Nucleic Acid-, Protein and Cell-related Technologies : Protein related
A computer-implemented method that allows calculating concentration ranges of components within complex networks of biochemical reactions.
Read more … Predicting Concentrations, Reactions Rates and Rate Constants in Biochemical Networks
Process for producing a mesoporous carbide
Ref.-No.: 0041-4518-WT
New Materials
Mesoporous materials present a large surface-to-volume ratio providing sites for catalysis, molecular separation, adsorption or chemical sensing. Some of the classical mesoporous materials employed include silica, alumina, zirconia, zeolites, and other diverse oxides such Ti or Co, and they are synthetized by routes as self-assembly, sol-gel, spray drying and some variations of these methods known in the state of the art. Additionally, some elements of the platinum group such as Pd, Ru, and their ...
Protein Cristallography (XDS)
Ref.-Nr.: 0105-1318-WT
IT / Software / Bioinformatics
X-ray Detector Software for processing single-crystal monochromatic diffraction data recorded by the rotation method.
Reducing phase singularities in speckle interferometry
Ref.-No.: 1629-5142-WT
Sensors, Devices and Components : Devices

Speckle interferometry is an established metrology technique for the characterization of rough objects. Deformations of rough objects under a load can be determined, as well as – with the help of an additional second wavelength – the surface shape of the object under test. As an illustration, Figure 1 (left) shows the so called raw phase as a result of a deformation measurement on a metal plate. The shape and the density of the fringes indicate the response of the metal plate to the load.
Owing ...
Read more … Reducing phase singularities in speckle interferometry
SIMNRA 7 software
Ref.-No.: 1801-4849-WT
IT / Software / Bioinformatics
SIMNRA is a Microsoft Windows program for the simulation of energy spectra for ion beam analysis with incident ions from about 100 keV to many MeV. SIMNRA can be used for the simulation of Rutherford backscattering (RBS), elastic backscattering with non-Rutherford cross-sections (EBS), nuclear reaction analysis (NRA), elastic recoil detection analysis (ERDA), and medium energy ion scattering (MEIS). Almost 3000 different non-Rutherford and nuclear reactions cross-sections for incident protons, ...
Simple, one-step assay for reliable measurements of NAD(H) and NADP(H) in complex samples
Ref.-Nr.: 0105-5434-IKF
Analytics
A simple, one-step assay for reliable measurements of NAD(H) and NADP(H) in complex samples, with various applications such as enzymatic assays, clinicals tests, and as point of care tests in the field of ageing.
Soft Capsule Endoscope - "B-MASCE"
Ref.-No.: 0104-5410-BC
Sensors, Devices and Components

Im Zuge der stetigen Weiterentwicklung und Nachfrage auf dem Gebiet der minimal invasiven Chirugie wurde am Max-Planck-Institut für intelligente Systeme in Stuttgart im Team von Herrn Prof Sitti für patientenfreundliche Magen-Darm-Untersuchungen ein kabelloses kapselförmiges Endoskop in Pillengröße, das sogenannte "B-MASCE" entwickelt. Die aus einem Elastomer bestehende Kapsel dient hierbei sowohl als Gehäuse als auch als Federelement für die Nadel. Über in der Kapsel eingebaute Magnete ...
Substituted Imidazolium Sulfuranes and their use as novel Electrophilic Group-Transfer Reagents
Ref.-No.: 0042-5063-LC
Processes and Methods (incl. Screening) : Chemical
Research Tools : Other
New Materials

The ability of hypervalent iodine compounds to act as electrophilic group-transfer reagents has been extensively exploited during the last several years in a variety of synthetically useful transformations
like cyanations and alkynylations. Now it was found, that novel imidazolium sulfuranes, which are isolobal to I(III) species and also depict the key threecenter four-electron bond motive, can be used as an alternative platform for the development of new electrophilic group-transfer reagents.
Imidazolium ...
SUMOvera: A Truly Orthogonal Cleavage Module
Ref.-Nr.: 0402-5439-LI
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Research Tools : Other
Nucleic Acid-, Protein and Cell-related Technologies : Protein related
SUMOvera enables versatile purification strategies for broad applications in eukaryotic hosts.
Superamphiphobic membranes for gas exchange and scrubbing
Ref.-No.: 0903-4616-LC
New Materials

Novel gas exchange membranes based on superamphiphobic coatings applied on metal meshes were created and tested in different applications, like gas scrubbing and blood oxygenation.
By using the novel membrans drawbacks of traditional membranes - like insufficient wetting, plugging and depositions chemical incompatibility and temperature instability - can be avoided.
Read more … Superamphiphobic membranes for gas exchange and scrubbing
Synchrotron Serial Snapshot Crystallography of Biological Nanocrystals carried in Microscopic, Ultra-Slow, High Viscosity Free-Streams
Ref.-No.: 0105-4794-IKF
Analytics
Processes and Methods (incl. Screening) : Physical
An apparatus and method allowing high throughput collection of X-ray diffraction data at room temperature.
The Camera Offset Space: Real-time Potentially Visible Set Computations for Streaming Rendering
Ref.-Nr.: 1200-5472-BC
IT / Software / Bioinformatics

The presented technology offers an enhanced streaming rendering pipeline that enables the display of high fidelity, high framerate and high solution for noval views in real time on thin lightweight HMDs suitable especially for VR experiences.
How does it work?
The key idea of this technology is based on a novel algorithm for Potentially Visible Set (PVS) creation: the camera offset space (COS), which for a given point on the image plane provides information under which camera ...
The Data Plotting Software DISLIN
Ref.-No.: 0704-1308-WT
IT / Software / Bioinformatics
DISLIN is a high level library of subroutines and functions that display data graphically. It is intended to be a powerful and easy to use software package for programmers and scientists that does not require knowledge of hardware features. The software is available for the programming languages C/C++, Fortran 77 and Fortran 90/95. For some operating systems, the languages Perl, Python, Java, Ruby, TCL and the C/C++ interpreter Ch are also supported.
DISLIN can display graphic information ...
Ultrafast Charging-Discharging of Nano-sized Na₃V₂(PO₄)₃ Embedded in Porous Carbon Matrix for Sodium Ion Batteries
Ref.-No.: 1201-4746-LC
Processes and Methods (incl. Screening) : Chemical
New Materials

We offer the new composite nanomaterial for sodium ion battery cathodes. These carbon-coated nanosized Na3V2(PO4)3 particles embedded in a highly effective mixed conducting porous carbon matrix can be easily prepared by means of facile soft-chemistry based preparation method with a post heat treatment procedure. The resulting cathodes can be charged and discharged in 6 s with high current density of 22 A/g, deliver the specific capacity of 44 mAh/g and ...
Unique multifunctional oligonucleotide enabling ultrafast RNA-protein interactions in cells and other uses thereof
Ref.-No.: 0214-5029-MG
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Research Tools : Other
Nucleic Acid-, Protein and Cell-related Technologies : Nucleic acid related
Nucleic Acid-, Protein and Cell-related Technologies : Protein related
Unique multifunctional oligonucleotide for the ultrafast transcriptome-wide identification of RNA-binding protein (RBP) targets.
Water content sensor for biological soil crusts
Ref.-No.: 0901-4720-WT
Sensors, Devices and Components

In arid and semiarid regions biological soil crusts (BSC) cover about 1/3 of the soil surface. As far as it is known, these BSC (consisting of cyanobacteria, algae, fungi, bryophytes, and other bacteria living in contact with soil particles) are crucial for the global terrestrial carbon and nitrogen cycle. The water status plays a major role, since their water content directly controls the activity of these poikilohydric organisms.