Technology Offers

Our scientists have identified a conserved defense mechanism covering a new metabolite in tobacco that protects against leafhoppers. They have discovered how to reconstitute it in vitro and engineer the compound in crop plants, demonstrating that it confers resistance to herbivores.

File no.: MI-1012-5677-LI-ZE
(liked to MI-1012-4430-LI-ZE describing the generation of neuro- epithelial stem cells as precursors for microtissue generation)

A robust method for producing and analyzing highly homogenous human neural organoids.

Recently, many efforts have been made to improve growth and yield of crop plants. CO₂ fixation in plants is primarily catalyzed by the enzyme ribulose-1,5-bisphosphate carboxylase (Rubisco). The inherent inefficiency of Rubisco necessitates an additional metabolic process termed photorespiration, which results in the loss of carbon and energy. In fact, it has been estimated that plants lose approximately 25% of the fixed carbon due to photorespiration. Despite several attempts to improve ...

With approximately 600,000 deaths annually colorectal cancer (CRC) is one of the most common cancer types worldwide. Early cancer and pre-cancer (polyps) detection by colonoscopy over the age of 50 until now is the best strategy for disease control and the chance of the cancer to be curable. Epigenetic changes such as DNA methylation has been shown to occur already at early stages of tumor development making such differentially methylated regions (DMRs) highly attractive for biomarker development ...

Cancer remains a major health burden and is the second leading cause of death globally (WHO). The microenvironment of cancer cells plays an important role in disease progression. In particular, the composition of the extracellular matrix regulates angiogenesis, cell proliferation, differentiation, cell survival and apoptosis. Dysregulation and accumulation of the extracellular matrix promotes cellular transformation and metastasis leading to cancer progression. A better understanding of the role ...

In contrast to target-based drug discovery, phenotypic screening discloses the effect of a compound on a biological system without revealing its mode of action or its interaction sites. Phenotypic screening has delivered several new valuable drugs, however, the major challenge remains target deconvolution (1). In recent years, “omics” techniques and bioinformatics have brought significant advances to target identification in drug discovery phenotypic screening. However, such analyses can become ...

In optical microscopy, especially within biological and medical fields, image quality is often degraded by light scattering and aberrations, such as often encountered when investigating partially transparent or scattering materials such as biological tissues. By using a spatial light modulator, one can mitigate these problems, but the challenge lies in determining the particular encountered aberration and calculating the required correction. This is additionally complicated by the microscopy imaging ...

Conventional mechanical zippers find manifold applications for luggage, clothing or even industrial applications. However, their design features significant disadvantages. In particular, they require the use of both hands by the user to align the ends of the garment and lock the insertion pin into the slider. This mechanism can be prone to jamming and failure and more generally requires the user to free his or her hands. The user must further use one or both hands to move the slider along the ...

Prof. Alois Fürstner and co-workers at Max Planck Institut für Kohlenforschung developed a new class of molybdenum alkylidyne catalysts equipped with tripodal silanolate ligands which mark a significant milestone in the field of alkyne metathesis. Their improved stability, functional group tolerance, and ease of synthesis position them as valuable tools for researchers and industry professionals alike, promising to expand the scope of alkyne metathesis applications ...

Ultrasound is being used in many fields ranging from medical imaging and therapy to non-destructive testing, contact-free particle handling or spatially selective heating in industrial settings. Often, those applications require shaping (including focusing) of an ultrasonic field. Compared to existing transducers with fixed lenses or phased array transducers (PATs) the present invention allows much more sophisticated sound fields to be generated using much simpler and cheaper technology.

The development of the cation channel channelrhodopsin-2 (ChR2) from Chlamydomonas reinhardtii by Prof. Ernst Bamberg and his colleagues and its application to light-induced modulation of neurons paved the way for the field of optogenetics.
Over time the light-gated cation channel channelrhodopsin-2 (ChR2) has become an indispensable tool in neuroscience. Based on the pioneering work on ChR2 new variants have emerged, differing in their spectrum of light absorption, their kinetic ...

To monitor crystallization processes a special camera setup to measure the crystal size and 3D shape distribution was developed.
The setup consists of two high-speed cameras that are positioned orthogonally to one another such that a precise overlap of both fields of view can be achieved. The setup further contains a specially designed flow-through cell that allows to observe the crystal suspension from both camera directions and given the opportunity to temperate the solution within the cell. ...

Die Erfindung betrifft einen Bildleiter, der insbesondere für den Einsatz in einer Umgebung mit radioaktiver Strahlung geeignet ist. In einer solchen Umgebung verringert sich die Transmission des Bildleiters mit der Zeit. Bekannterweise kann die Transmission des Bildleiters durch Erwärmen auf eine Temperatur im Bereich von 100° bis 300° regeneriert werden. Weil dieses Erwärmen bisher in einem Ofen erfolgte, implizierte das Regenerieren des Bildleiters seinen Abbau von seinem Betriebsort, ...

The diterpenoid paclitaxel (taxol) is a chemotherapy medication widely used as a first-line treatment against several types of solid cancers. However, adequate supply has remained a major challenge. Extraction of paclitaxel from natural sources is limited, while the chemical synthesis is complex and economically unfavourable. Currently paclitaxel is mainly produced by microbial fermentation or in plant cell cultures with low overall yields. Ideally, paclitaxel production is reconstructed in a ...

A lightweighted,  long-life, long-range and low-cost Bluetooth Low Energy (BLE)-based tracking system with monitoring app.

The offered invention relates to a device that reduces free-jet instabilities inherent to high-viscosity extrusion injection, facilitating delivery of protein microcrystals for serial diffraction X-ray crystallography.

The unicellular green alga Chlamydomonas reinhardtii is both an invaluable model organism for plant biology and an attractive biotechnological production system for biofuels and biopharmaceuticals. Despite the availability of efficient methods for introduction of foreign genes into the nuclear genome of the alga, transgene expression levels are usually very poor. This is a serious limitation that has severely hampered both post-genomics research in Chlamydomonas and use of the ...

Database of mass spectral and retention index data of metabolomic reference substances for GC/MS profiling studies.

The connector apparatus incorporates a unique design that allows two or more conductor devices to contact directly, ensuring zero-resistance connections under superconducting conditions. This is facilitated by a pivoting pressing clamp mechanism, which when engaged, applies precise contact pressure to overlapping conductor sections housed within a specially designed connector receptacle. This innovative configuration is critical for applications requiring minimal electrical resistance and high ...

Cryogenic fluorescent light microscopy of flash-frozen cells presents significant advantages and provides an important complement to electron cryo-microscopy. In particular, bleaching decreases drastically at low temperature while the fluorescence yield of many fluorophores increases and the spectral bands narrow. The application of modern super-resolution methods such as STED, PALM, STORM, or SIM at cryogenic temperature holds the prospect of imaging fluorescent proteins with high precision in ...

Lock-in thermography (LIT) is a versatile and very sensitive tool to detect local heat sources in electronic components by 2d-images oft he sample. The DECONV program is a tool for converting these lock-in thermography images into local power density images or simulating LIT images by performing mathematical deconvolution or convolution and uses input image data in ASCII table form. Results are exported as ASCII tables or as bmp-files.

This software is a further development of an older ...

Light microscopy enables fascinating insights into the microcosm of life. It is one of the key techniques in life science and provides access to a better understanding of biology across many orders of magnitude in time and space. The use of visible light allows for minimally invasive imaging - even of living cells - and direct observation with the human eye. However, the use of visible light limits the resolution of the image obtained to about half the wavelength of the used light. The limiting ...

Engineering light distributions in a three-dimensional volume to achieve selective illumination profiles is an instrumental task shared by many optical and microscopy techniques. The optimization of the light distribution can lead to significant enhancement of relevant performance figures and ultimately to the extension of the instrument or experimental protocol capabilities^1,2,3,4,5. Targeted illumination profiles can be used either to mechanically interact with molecules at nanometer ...

This software is based on the paper "Quantitative evaluation of electroluminescence images of solar cells" by O. Breitenstein et al.¹). It allows to load a number of electroluminescence (EL) images to different biases, which have to be given as ASCii tables.

We offer an innovative aqueous composition that promotes ice nucleation at high efficiencies, even at extremely low concentrations of ice-nucleating particles. This breakthrough is particularly relevant in the fields of agriculture, atmospheric science, and the biosphere, where the control over ice formation can significantly impact environmental dynamics and technological applications.

The invention relates to a new and durable system, which brings the possibility of accurate size measuring and simultaneous counting of airborne particles with an aerodynamic diameter of up to 2.5 microns.

Measuring the particulate matter contamination in a gas in the range of PM_2.5 is advantageous or crucial for various applications. Monitoring the concentration of the corresponding particles, for example in air, reveals information about pollution. The possibility of aerosol ...

A novel green chemistry process to prepare nanocellulose in efficient, safe and sustainable manner based on the use of eutectic, highly concentrated ionic media is offered.

LEL technology stands out for its precision in fabricating 3D metal microarchitectures with intricate geometries and the ability to seamlessly integrate liquids. It utilizes a voxel-by-voxel deposition method, which allows for the creation of complex shapes with submicron resolution. The process involves optimizing variables like deposition voltage, air pressure, and orifice diameter. A significant advantage of LEL is its capacity to alter the pH and composition of the supporting electrolyte solution, ...

The invention relates to a new monolithic Avalanche Photodiode array with a novel inter pixel isolation structure. The technology allows the design of sensitive photodetectors with remarkable spatial resolution at very fast imaging capabilities for various applications.
Although Avalanche Photodiodes are a convenient tool due to their intrinsic amplification, their use in photodetectors with high pixel densities is challenging due to insufficient isolation of the pixels. Hence their use in ...

A double KO, a conditional KO as well as single KO mouse models for FFA2 and FFA3 (free fatty acid receptors 2 and 3), novel targets for diabetes therapies.

Accurate dispensing device for intuitive, spill free use

Nanoporous membranes consist of pores with diameters in the range of nanometers and sub nanometers that can separate liquid or gaseous mixtures.
One of the key applications of nanoporous membranes is in water filtration to remove impurities, such as bacteria, viruses, and salts. Nanoporous membranes are also used in energy-related applications, such as gas separation and fuel cells. The membranes can also be used as electrodes in energy storage devices such as batteries and supercapacitors. ...

Conjugation of a NAD-capped nucleic acid to a protein catalysed by an ART to generate novel RNA therapeutics.

Precise genome editing demands for homology-directed repair (HDR) by aiming to introduce a new double stranded DNA substituting for a homologous sequence but partially defect one. This substrate dependent reaction does compete with direct non-homologous end joining (NHEJ) of the double strand breaks. NHEJ is error-prone and is therefor mainly used for gene inactivation.
The rate of NHEJ is directly limiting the rate of HDR. For this reason HDR in vitro does occur on a very low level only and ...

Connectase is an enzyme that fuses target proteins or synthetic compounds via a small recognition tag, using a different reaction mechanism compared to known protein ligases. It prevents side reactions entirely and has absolute specificity, even in highly in complex solutions with minimum concentrations of target molecules.

We offer a new simple and low cost technology to fabricate graphene-encapsulated metal or metal compound nanoparticles. The resulting hybrid nanoparticles are protected by granted substance claims in US, CN, TW and EP (DE, FR, GB, BE). Currently the patent protected graphene coated nano particles are discussed as high performance electrode materials in the lithium ion battery business (for example Samsung's "Graphene Balls").

The invention relates to a new method of producing SnTiO3 for the use as a ferroelectric element. Tin titanates are known to be a class with various properties making it promising for many applications. The preparation of this material beyond thin films remained challenging.

Tin(II) oxide has a low disproportionation temperature of 350°C but the preparation of new materials is usually conducted at higher temperatures. Therefore, bulk SnTiO3 is not possible to be produced using existing ...

The CRISPR-Cas system is a powerful tool for site-specific genome editing. It allows for the inactivation or substitution of entire genes. However, most hereditary diseases in humans are caused by single point mutations, the correction of which requires only subtle changes to the DNA. Recently, base editors (BEs) were developed that allow the introduction of selective nucleotide substitutions. A Cas9 enzyme is fused to a nucleobase deaminase catalysing C-to-T mutations (by C-to-U deamination) ...

The Differential Temperature Anemometry (DTA) is a cutting-edge technique that enhances the temporal resolution of flow velocity measurements in thermal anemometry. By leveraging the in-stantaneous temperature gradient of the sensor, DTA provides rapid and continuous data without the need for thermal equilibrium. This innovation represents a significant leap forward, offering high-speed, accurate flow detection for dynamic applications.

The invention relates to a new and easy to use device for real-time monitoring of the thermal power of a nuclear reactor. It is based on the easy to access ¹⁶N decay rate in the cooling water. The robust and easy to implement method significantly improves the safety of nuclear facilities.

Nuclear reactors require high standards of safety and detailed information about changes are needed in order to control them in a safe manner. Besides detailed real-time simulations, direct ...

This innovative ion beam extraction system enhances flexibility in beam parameter adjustment and improves the efficiency of ion beam generation. The system combines an ion source with an adjustable grid assembly, where grid spacing can be precisely controlled via a motorized mechanism. This setup allows for optimal perveance tuning and minimizes beam divergence, significantly improving performance under varying operating conditions. While primarily designed for Neutral Beam Injection (NBI) in ...

A laser device (100), configured for generating laser pulses, has a laser resonator (10) with a gain disk medium (11) and a Kerr medium (12). The laser resonator (10) includes a first mode shaping section (13) which is adapted for shaping a circulating electric field coupled into the gain disk medium (11), and a second mode shaping section (14), which is adapted for shaping the circulating electric field coupled into the Kerr medium (12) independently of the electric field shaping in the first ...

The LITESEC-T3SS (Light-induced translocation of effectors through sequestration of endogenous components of the T3SS) system represents a novel, fast, specific, and reversible method to control protein secretion into eukaryotic cells, enabling various medicinal and biotechnological applications, such as targeted drug delivery for tumor therapy.

Scientists from Max Planck Institute for Intelligent Systems developed a low-power opto-electronic computing device that is capable of implementing multiple layers of an artificial neural network which is scalable enough to accommodate operation speeds required by modern artificial neural networks.

MARS is a powerful program for robust automatic backbone assignment of proteins. MARS is applicable to proteins with extreme chemical shift degeneracy such as high molecular weight proteins and partially disordered or fully intrinsically disordered proteins. MARS is successfully used in many labs world-wide as evidenced by a huge number of citations.

This disclosure presents a method and device for precisely measuring the frequency of a scanning diode laser. Applications include LIDAR, gas sensing and spectroscopy of integrated photonic devices like microresonators. The method involves a tunable laser, modulated at two distinct frequencies to generate side band resonances while it is being scanned across a reference cavity (e.g. a fiber loop resonator). This setup enables precise and instantaneous measurement of the optical frequency and tuning ...

The present invention relates to a method of generating pulsed coherent radiation in the UV and XUV wavelength ranges. Furthermore, the present invention relates to a radiation source for generating pulsed coherent radiation based on a high harmonic generation (HHG).

The invention relates to a new method for an improved production of random numbers and verification of their randomness. In order to do so, it uses the quantum mechanical properties of microscopic particles and structures. A number sequence is generated by means of a repetitive quantum mechanical random process. The measurement of this process is performed by a homodyndetection of an optical input signal, where the signal interferes with a local oscillator, e.g. a laser, at a central beam splitter ...

Biological fixation of CO₂ is an important process carried out by plants and several microorganisms, which can be harnessed for sustainable, biobased production of fuels and chemicals. Particularly, the fixation of CO₂ by autotrophic microorganisms such as cyanobacteria and microalgae can be employed for converting CO₂ into value-added products, such as commodity chemicals or fuels. However, the sustainable autotrophic production ...

The MINSTED method is an innovative technique for determining the position of a singularized fluorophore molecule within an object. Traditional methods in molecular imaging faced challenges in achieving high resolution due to limitations in fluorescence microscopy. Existing solutions like STED (Stimulated Emission Depletion) microscopy improved the spatial resolution but rely on high illumination intensity and/or sample exposure, which can lead to thermal issues and photochemical reactions. MINSTED ...

A synthetic virus-like particle, comprising a lipid bilayer, that can be adjusted precisely to mimic biophysical features of various natural pathogens. The lipid bilayer can also be equipped with relevant molecules such as the SARS-CoV-2 spike protein ectodomain.

A tRNA^ALA heteroplasmy mouse model to study mitochondrial disorders such as encephalomyophathies, that recapitulates symptoms as observed in human patients with disease-causing mutation in the same mitochondrial gene.

Exploiting the benefits offered by magnetic resonance imaging (MRI) at ultra-high fields (≥ 7 Tesla) requires optimized radiofrequency (RF) coils. MRI at UHF operates in a regime where the RF wavelength is comparable to the dimensions of the sample size, resulting in an inhomogeneous distribution of the transmit field (B₁⁺) and in an impaired image quality. An array of independent transmit coils arranged in multiple rows provides the degrees of freedom to influence the ...

We offer a new family of cationic ligands, namely N-alkyl/aryl pyridiniophosphines. The ligands can be synthesized through a short, scalable, and highly modular route.

Evaluation of their electronic properties evidenced weak σ-donor and quite strong π-acceptor character when used as ancillary ligands.

A group of scientists at the MPI for Polymer Research in Mainz developed nano-graphene structures that can be used as a new class of fluorophores for super-resolution microscopy (SMLM and STED).

They perform like hybrids of organic dyes and QDs: they have excellent environment-independent blinking properties, emit high photon numbers, display high photo-stability, possess low toxicity, have a molecular size below 2 nm, and have narrow excitation and emission spectra.

These nanographene ...

File no.: MI-1012-4430-LI-ZE
(liked to MI-1012-5677-LI-ZE describing the generation of human neural microtissues from NECS cells)

A novel precursor population that forms electrophysiologically functional neurons more quickly than protocols starting with hPSCs.

We present an extremely sensitive, reliable and fast novel Lysine deacetylase (KDAC) assay, which can be performed in a continuous format. This novel KDAC assay is based on Firefly luciferase harboring an acetylation on an essential active site lysine, incorporated by genetic code expansion.

We furthermore offer a bacterial selection system that can help engineer KDACs. The selection system uses a reporter enzyme inactivated by lysine modifications at an essential active site residue, thereby ...

A classical spin valve (SV) is a device in which the electrical resistance depends on the relative position of the magnetic moments of two ferromagnetic (FM) layers: with parallel (P) and antiparallel (AP) ordering, the SV resistance is minimum and maximum, respectively. Nowadays SVs are actively used in magnetic sensors, hard disk read heads and magnetic random-access memory. Thus, the SV, analogous to a transistor in conventional electronics, is a binary (digital) device. Here we offer a new ...

Crystallization is the limiting step in X-ray structure determination of biological macro-molecules. As crystallization experiments can be largely automatized, the diversity of precipitant solutions is often the determinant factor to obtain crystals of high quality.

HR-defective cancers are a class of malignancies characterized by impaired DNA repair mechanisms, typically resulting from mutations or deficiencies in genes involved in the Homologous Recombination (HR) pathway, such as BRCA1 and BRCA2. These cancers pose significant challenges in treatment due to their inherent resistance to standard therapies.

Poly ADP-ribose Polymerase 1 (PARP1) inhibitors represent a promising targeted therapy class designed to exploit ...

To realize a circular, carbon-neutral economy, it will become important to utilize the greenhouse gas CO2 as a sustainable carbon source. One-carbon (C1) substrates, such as methanol or formate, are attractive feedstocks for bioeconomy due to their low cost and easy availability. These substrates are typically converted into formaldehyde, serving as the entry point into metabolism. Biocatalytic carbon-carbon bond formation is one of the most important reactions for green and sustainable C1 assimilation ...

Plant pathogenic fungi, oomycetes and bacteria have highly diverse lifestyles, infection strategies and morphologies. Therefore, pesticides frequently target basic cellular processes, as these are well characterized and often very similar among plant pathogens. Many pesticides target enzymes that play a role in e.g. nucleic acid synthesis, respiration, cell division and other essential cellular processes. However, the molecular ...

Chiral amines are crucial building blocks for the synthesis of bioactive compounds in the pharmaceutical, and agrochemical industry. Chiral amines are also important for chemical synthesis as chiral auxiliaries or resolving agents for diastereometric salt crystallizations. In recent years, biocatalysts, particularly imine reductases (IREDs) and reductive aminases capable of reducing imines to chiral amines were discovered and developed for industrial application. However, the portfolio of current ...

Pancreatic cancer continues to pose significant challenges in the field of oncology, with dismal survival rates and limited treatment options. Patients diagnosed with this aggressive malignancy often face an uphill battle, with a five-year relative survival rate of just 11%.

Ras proteins are well-known as pivotal regulators of cell growth, proliferation, and differentiation, with their dysfunction implicated ...

Cancer stands as the second-leading cause of human death worldwide, following closely behind cardiovascular and cerebrovascular diseases, with a prevalence that continues to rise.

Pancreatic cancer, in particular, continues to challenge the field of oncology with a 5-years survival rate of 11% and limited treatment options. Hematologic malignancies have also seen a steady rise in incident cases since 1990, ...

This invention relates to an optical fiber vacuum feedthrough designed to transmit optical signals between the inside and outside of the vacuum chamber. Traditional methods often require frequent replacement of flanges or optical fibers due to leakage over time, and the high pressure applied to the optical fibers led to transmission losses. In order to address these issues, the presented optical fiber feedthrough comprises a compression device which compresses sealing elements axially along the ...

For the evaluation of crystallisation processes, process parameters like temperature and concentration can be easily measured. However, to measure the crystal size distribution continuously is a challenging task.
Different methods relaying on back scattering or reflection of monochromatic light can be applied that yield chord-length distributions, which often deviate from the actual crystal or particle size distribution. For analysing the true crystal dimensions and, additionally, the crystal ...

The mRNA processing factor YBX1 is a novel target in Myeloproliferative neoplasms (MPNs), which in an combinatorial inhibitor treatment with JAK inhibitors completely overcomes disease persistance.

A process for parallel synthesis of glycans on cellulose membranes by using a novel VaporSPOT method and an experimental setup that ensures controlled conditions suitable for glycosylation reactions.

Point patterns are characterized by their density and correlation. While spatial variation of density is well-understood, analysis and synthesis of spatially-varying correlation is an open challenge. We offer a tool for intuitively editing point patterns, based on a compact representation for spatially varying correlation. We can map point patterns to common three-channel raster images, enabling manipulation with off-the-shelf image editing software. To synthesize back point patterns, we propose ...

This invention presents a series of photoactivatable fluorescent dyes characterized by their hydrophilic caging groups. These novel compounds are primarily designed for bioimaging applications, allow for controlled photoactivation at the desired wavelengths and exhibit enhanced solubility in aqueous environments. The technology facilitates high-precision imaging techniques, including super-resolution fluorescence microscopy and single-molecule tracking, by enabling precise spatial and temporal ...

The invention relates to a new device for precise large-angle beam steering at an extended wavelength range. It is based on an electrically-controlled metasurface and allows for the implementation in advanced LIDAR systems.

Metasurfaces are used to change properties of light and can therefore be used to steer an incoming beam. However, common devices are lacking spatial resolution and are thus limited to small angles. Furthermore, state-of-the-art metasurfaces for respective applications ...

Mesoporous materials present a large surface-to-volume ratio providing sites for catalysis, molecular separation, adsorption or chemical sensing. Some of the classical mesoporous materials employed include silica, alumina, zirconia, zeolites, and other diverse oxides such Ti or Co, and they are synthetized by routes as self-assembly, sol-gel, spray drying and some variations of these methods known in the state of the art. Additionally, some elements of the platinum group such as Pd, Ru, and their ...

Direct quantification of the absolute amount of multiple proteins in one a SILAC experiment using Protein Epitope Signature Tags (PrESTs) which consist of a short and unique region of the protein of interest as well as purification and solubility tags and are expressed recombinantly in E. coli

Driven by the favourable operational effectiveness of neodymium iron boron (NdFeB) magnets, there has been a considerably rising demand for neodymium in permanent magnet manufacturing. According to Spherical Insights & Consulting the global neodymium magnet market size was valued at 2.3 Billion US$ in 2022 and is expected to reach 3.83 Billion US$ by 2032. As the market for rare earth materials is heavily influenced by Chinese supplies, which causes supply and price uncertainties, end users ...

Speckle interferometry is an established metrology technique for the characterization of rough objects. Deformations of rough objects under a load can be determined, as well as – with the help of an additional second wavelength – the surface shape of the object under test. As an illustration, Figure 1 (left) shows the so called raw phase as a result of a deformation measurement on a metal plate. The shape and the density of the fringes indicate the response of the metal plate to the load.
Owing ...

The invention relates to the actuation of micro- and nanostructures controlled by external stimuli. Photo-actuation utilizes the conversion of light via phonons into motion through reversible chemical and physical processes and enables remote and spatiotemporal control of the actuation. Here, we report a fast light-to-motion conversion in few-nanometer thick bare polydopamine (PDA) membranes stimulated by (visible) light. Light-induced heating of PDA leads to desorption of water molecules and ...

We present a sensor for the carrier-envelope phase of a few-cycle femtosecond laser. The sensor uses the electron current emitted from a nanoscale metal tip onto which we focus high-repetition-rate laser pulses.

Possible applications of this sensor are in the field of the technique of controlling and using pulse lasers, in particular used for measuring or high-power irradiation purposes.

The size of such a simple stand-alone sensor device for the carrier-envelope phase could be in ...

SIMNRA is a Microsoft Windows program for the simulation of energy spectra for ion beam analysis with incident ions from about 100 keV to many MeV. SIMNRA can be used for the simulation of Rutherford backscattering (RBS), elastic backscattering with non-Rutherford cross-sections (EBS), nuclear reaction analysis (NRA), elastic recoil detection analysis (ERDA), and medium energy ion scattering (MEIS). Almost 3000 different non-Rutherford and nuclear reactions cross-sections for incident protons, ...

Fluorescence microscopy is one of the key techniques in the life and materials sciences, with applications ranging from routine diagnostics to state-of-the-art research investigations. Key to this success has been its intrinsic advantages combined with continuous improvement in its fundamental features such as resolution, speed, and sensitivity.

Two key challenges are fast single-fluorophore imaging of multi-color samples. This need arises in a broad range of settings such as very high-resolution ...

RNA plays a vital role in gene expression regulation, and its dysregulation is linked to diseases such as cancer, neurodegeneration, and viral infections. Targeting RNA-binding proteins or RNAs, such as microRNAs (miRNAs) and mRNAs, represents an emerging area in drug discovery. However, traditional RNA-binding small molecules often rely on linear hydrophobic aromatic scaffolds, which limit chemical diversity and therapeutic potential. This invention introduces azetidine-based small molecules, ...

Im Zuge der stetigen Weiterentwicklung und Nachfrage auf dem Gebiet der minimal invasiven Chirugie wurde am Max-Planck-Institut für intelligente Systeme in Stuttgart im Team von Herrn Prof Sitti für patientenfreundliche Magen-Darm-Untersuchungen ein kabelloses kapselförmiges Endoskop in Pillengröße, das sogenannte "B-MASCE" entwickelt. Die aus einem Elastomer bestehende Kapsel dient hierbei sowohl als Gehäuse als auch als Federelement für die Nadel. Über in der Kapsel eingebaute Magnete ...

This invention relates to means and methods for conjugating/attaching target molecules such as proteins to a label and/or carrier.

The ability of hypervalent iodine compounds to act as electrophilic group-transfer reagents has been extensively exploited during the last several years in a variety of synthetically useful transformations
like cyanations and alkynylations. Now it was found, that novel imidazolium sulfuranes, which are isolobal to I(III) species and also depict the key threecenter four-electron bond motive, can be used as an alternative platform for the development of new electrophilic group-transfer reagents.

Imidazolium ...

SUMOvera enables versatile purification strategies for broad applications in eukaryotic hosts.

The invention relates to a new solar battery half-cell that can be recharged by natural resources like sunlight. Remarkable sustainability is provided by the possibility to use sunlight as a source of primary energy and by solving the problem of low capacity of state-of-the-art battery technologies.

Sustainable solutions for efficient storage of electrical energy are of great importance for the global energy transition and other applications. Typical batteries, however, are often charged ...

Lytic bacteriophages, or phages, possess a unique ability to replicate by infecting and destroying bacterial hosts, offering vast potential in medical and biotechnological fields. Their applications span across clinical and industrial sectors, including phage therapy for treating and preventing bacterial infections in humans, such as enteric diseases, skin infections, chronic conditions, and sepsis. Beyond healthcare, phages can help reduce bacterial virulence and antibiotic resistance, preserve ...

The presented technology offers an enhanced streaming rendering pipeline that enables the display of high fidelity, high framerate and high solution for noval views in real time on thin lightweight HMDs suitable especially for VR experiences.

How does it work?

The key idea of this technology is based on a novel algorithm for Potentially Visible Set (PVS) creation: the camera offset space (COS), which for a given point on the image plane provides information under which camera ...

This innovative nanosheet-based sensor offers remarkably high sensitivity and rapid response times, making it ideal for advanced touchless positioning interfaces (TPI) and environmental monitoring. By utilizing 2D nanosheet materials, the sensor achieves sub-centimeter spatial resolution and can detect gases and humidity with remarkable accuracy. It is based on a nanosheet of active material (H₃Sb₃P₂O₁₄) that changes its electrical or optical properties ...

The invention relates to a new, ultracompact non-invasive medical ventilation system. The BIPAP (Biphasic Positive Airway Pressure) ventilation unit, of size and weight of a tennis ball, is easy to handle and allows low-budget mass production. It can be powered by a rechargeable battery-pack – a great advantage in case of mobile use or damaged/unstable infrastructure leading to frequent blackouts. These benefits, ...

Unique multifunctional oligonucleotide for the ultrafast transcriptome-wide identification of RNA-binding protein (RBP) targets.