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Ref.-No.: 0204-3324-IKF

Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine : Vaccines

"Novel first-in-class intra-nasally applicable safe recombinant "vir4vac" RNA vaccines constitute a very safe and efficacious way of preventing serious infections of respiratory corona and paramyxoviruses as well as other respiratory viruses.“

Ref.-Nr.: 0301-4550-LI

Medicine : Diagnostics

With approximately 600,000 deaths annually colorectal cancer (CRC) is one of the most common cancer types worldwide. Early cancer and pre-cancer (polyps) detection by colonoscopy over the age of 50 until now is the best strategy for disease control and the chance of the cancer to be curable. Epigenetic changes such as DNA methylation has been shown to occur already at early stages of tumor development making such differentially methylated regions (DMRs) highly attractive for biomarker development ...

Ref.-No.: 0105-5855_1-IKF

Medicine : Therapeutics
Medicine : Animal Models
Nucleic Acid-, Protein and Cell-related Technologies

Cancer remains a major health burden and is the second leading cause of death globally (WHO). The microenvironment of cancer cells plays an important role in disease progression. In particular, the composition of the extracellular matrix regulates angiogenesis, cell proliferation, differentiation, cell survival and apoptosis. Dysregulation and accumulation of the extracellular matrix promotes cellular transformation and metastasis leading to cancer progression. A better understanding of the role ...

Ref.-No.: 0105-5855_2-IKF

Medicine : Therapeutics
Medicine : Animal Models
Nucleic Acid-, Protein and Cell-related Technologies

Fibrosis is the excessive accumulation of extracellular matrix that leads to destruction of the tissue architecture and consequently organ failure. In the developed world, an estimated 45 % of all deaths resulted from severe fibrotic diseases. A wide range of chronic diseases are able to induce fibrosis such as hepatitis, pulmonary disease, scleroderma and cancer. Current therapies for fibrosis are limited and of low efficacy. Further research on fibrosis is required to understand disease progression ...

Ref.-Nr.: 0305-3252-LI

Medicine : Therapeutics

Anthrax is an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis. B.anthracis can cause human disease via the gastrointestinal, cutaneous or inhalational routes. There is still a considerably high rate of mortality from inhalational anthrax of up to 75 percent, even though fluorquinolone class antibiotics (e.g., ciprofloxacin) are being administered as a first-line therapy. This strategy, in addition, is being threatened by the spread of plasmid-mediated ...

Ref.-No.: 0042-5371-LC / SGK A477

Processes and Methods (incl. Screening)
Medicine

Prof. Klaus-Richard Pörschke and co-workers from the MPI for Coal Research developed a highly hydrophobic perfluoroaryl borate (FAB) ligand for trapping the radioative 134/137 Cs isotopes with 100% specificity. The novel approach could improve the decontamination of humans compared to the administration of so called insouble Prussian blue currently in use.

Ref.-No.: 0603-5770-IKF

Medicine : Therapeutics

The semaphorin-plexin system consists of several classes of semaphorin ligands and of several classes of plexin transmembrane receptors that all together mediate cell-cell interactions in many different tissues in mammals under physiological conditions [1]. Beyond that, the semaphorin-plexin system also plays an important role in several pathophysiological processes, such as cancer, inflammatory and immune diseases, bone diseases and microvascular diseases [1]. In this respect, the semaphoring-plexin ...

Ref.-No.: 0042-5371-LC / SGK A477

Processes and Methods (incl. Screening)
Medicine

Prof. Klaus-Richard Pörschke and co-workers at the MPI for Coal Research developed a novel cyclic process for the quantitative extraction of cesium with 100% selectivity from any given aqueous or acidic solution, irrespective of the other components.

Ref.-No.: 0603-4987-IKF

Medicine : Therapeutics
Medicine : Animal Models
Nucleic Acid-, Protein and Cell-related Technologies : Protein related

A double KO, a conditional KO as well as single KO mouse models for FFA2 and FFA3 (free fatty acid receptors 2 and 3), novel targets for diabetes therapies.

Ref.-No.: 0706-5707-IKF

Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine : Drug delivery
Nucleic Acid-, Protein and Cell-related Technologies : Protein related

The LITESEC-T3SS (Light-induced translocation of effectors through sequestration of endogenous components of the T3SS) system represents a novel, fast, specific, and reversible method to control protein secretion into eukaryotic cells, enabling various medicinal and biotechnological applications, such as targeted drug delivery for tumor therapy.

Ref.-No.: 1013-4827-IKF

Medicine : Animal Models
Research Tools

A tRNAALA heteroplasmy mouse model to study mitochondrial disorders such as encephalomyophathies, that recapitulates symptoms as observed in human patients with disease-causing mutation in the same mitochondrial gene.

Ref.-No.: 1012-4727-IKF

Medicine : Diagnostics
Nucleic Acid-, Protein and Cell-related Technologies : Cell related

The mammalian skeletal system harbors a hierarchical system of skeletal stem cells, osteoprogenitors and osteoblasts sustaining lifelong bone formation [1, 2]. Osteogenesis is indispensable for the homeostatic renewal of bone as well as regenerative fracture healing, but these processes frequently decline in the aging organism. Loss of bone mass and increased fracture incidence are features of osteoporosis, which affects more than 25 million patients in the EU [3] and generates annual costs estimated ...

Ref.-Nr.: 0803-5480-IKF

Analytics
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine : Diagnostics
Nucleic Acid-, Protein and Cell-related Technologies : Protein related

Extremely sensitive, reliable and fast novel KDAC assay, which can be performed in a continuous format. This novel KDAC assay is based on Firefly luciferase harboring an acetylation on an essential active site lysine, incorporated by genetic code expansion. We furthermore offer a bacterial selection system for KDACs, which uses a reporter enzyme inactivated by lysine modifications at an essential active site residue, thereby linking deacetylase activity to a selectable output.

Ref.-No.: 0707-5639-MG

Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine : Therapeutics
Nucleic Acid-, Protein and Cell-related Technologies : Nucleic acid related

Antiviral therapy against retroviruses and alphaviruses using tRNALeu(UUA) overexpression

Ref.-Nr.: 1013-5354-IKF

Analytics
Medicine : Therapeutics
Medicine : Diagnostics
Research Tools : Other
Nucleic Acid-, Protein and Cell-related Technologies : Cell related

Biomarkers of ageing have long been sought after to help assess the biological age and general health status of individuals. Considerable efforts have been invested to identify such biomarkers, including physiologic readouts, metabolic parameters, glycomic profiles and others. Nevertheless, markers with strong predictive power have remained elusive.

Work in model organisms has identified several conserved signaling pathways that extend life span, such as reduced insulin/IGF signaling and ...

Ref.-Nr.: 0401-4561-MG

Medicine : Diagnostics

Synthetic Glycosylphosphatidylinositols (GPIs) with high selectivity and purity for Toxoplasmosis diagnosis and vaccine.