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Ref.-No.: 0204-3324-IKF

Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine : Vaccines

"Novel first-in-class intra-nasally applicable safe recombinant "vir4vac" RNA vaccines constitute a very safe and efficacious way of preventing serious infections of respiratory corona and paramyxoviruses as well as other respiratory viruses.“

Ref.-Nr.: 0301-4550-LI

Medicine : Diagnostics

With approximately 600,000 deaths annually colorectal cancer (CRC) is one of the most common cancer types worldwide. Early cancer and pre-cancer (polyps) detection by colonoscopy over the age of 50 until now is the best strategy for disease control and the chance of the cancer to be curable. Epigenetic changes such as DNA methylation has been shown to occur already at early stages of tumor development making such differentially methylated regions (DMRs) highly attractive for biomarker development ...

Ref.-No.: 0105-5855_1-IKF

Medicine : Therapeutics
Medicine : Animal Models
Nucleic Acid-, Protein and Cell-related Technologies

Cancer remains a major health burden and is the second leading cause of death globally (WHO). The microenvironment of cancer cells plays an important role in disease progression. In particular, the composition of the extracellular matrix regulates angiogenesis, cell proliferation, differentiation, cell survival and apoptosis. Dysregulation and accumulation of the extracellular matrix promotes cellular transformation and metastasis leading to cancer progression. A better understanding of the role ...

Ref.-No.: 0105-5855_2-IKF

Medicine : Therapeutics
Medicine : Animal Models
Nucleic Acid-, Protein and Cell-related Technologies

Fibrosis is the excessive accumulation of extracellular matrix that leads to destruction of the tissue architecture and consequently organ failure. In the developed world, an estimated 45 % of all deaths resulted from severe fibrotic diseases. A wide range of chronic diseases are able to induce fibrosis such as hepatitis, pulmonary disease, scleroderma and cancer. Current therapies for fibrosis are limited and of low efficacy. Further research on fibrosis is required to understand disease progression ...

Ref.-Nr.: 0106-5185-MG

Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine : Therapeutics
Nucleic Acid-, Protein and Cell-related Technologies : Cell related

Remodeling the morphology of mitochondria to manipulate immune cell metabolism and hence reduce immune cell activation and effector functions

Ref.-Nr.: 0305-3252-LI

Medicine : Therapeutics

Anthrax is an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis. B.anthracis can cause human disease via the gastrointestinal, cutaneous or inhalational routes. There is still a considerably high rate of mortality from inhalational anthrax of up to 75 percent, even though fluorquinolone class antibiotics (e.g., ciprofloxacin) are being administered as a first-line therapy. This strategy, in addition, is being threatened by the spread of plasmid-mediated ...

Ref.-Nr.: 0704-5610-BC

Medicine : Diagnostics
Sensors, Devices and Components

This novel screwless coupling, which can also be used as overload clutch, offers the possibility without additional tools to connect two rotatable elements even under extremely tight conditions, backlash-free and force fit with high precision. Due to their size, couplings known to date on the market are unsuitable for applications in the field of electronics, optics, metrology and precision engineering. Whereas thanks to the new technology, which was developed at the Max Planck Institute for Solar ...

Ref.-No.: 0603-4987-IKF

Medicine : Therapeutics
Medicine : Animal Models
Nucleic Acid-, Protein and Cell-related Technologies : Protein related

A double KO, a conditional KO as well as single KO mouse models for FFA2 and FFA3 (free fatty acid receptors 2 and 3), novel targets for diabetes therapies.

Ref.-No.: 0706-5707-IKF

Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine : Drug delivery
Nucleic Acid-, Protein and Cell-related Technologies : Protein related

The LITESEC-T3SS (Light-induced translocation of effectors through sequestration of endogenous components of the T3SS) system represents a novel, fast, specific, and reversible method to control protein secretion into eukaryotic cells, enabling various medicinal and biotechnological applications, such as targeted drug delivery for tumor therapy.

Ref.-No.: 1013-4827-IKF

Medicine : Animal Models
Research Tools

A tRNAALA heteroplasmy mouse model to study mitochondrial disorders such as encephalomyophathies, that recapitulates symptoms as observed in human patients with disease-causing mutation in the same mitochondrial gene.

Ref.-No.: 1012-4727-IKF

Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine
Nucleic Acid-, Protein and Cell-related Technologies : Cell related

A method to reprogram bone endothelial cells into cells that are able to mediate bone angiogenesis and osteogenesis, opening new avenues to treat osteoporosis.

Ref.-Nr.: 0803-5480-IKF

Analytics
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine : Diagnostics
Nucleic Acid-, Protein and Cell-related Technologies : Protein related

Extremely sensitive, reliable and fast novel KDAC assay, which can be performed in a continuous format. This novel KDAC assay is based on Firefly luciferase harboring an acetylation on an essential active site lysine, incorporated by genetic code expansion. We furthermore offer a bacterial selection system for KDACs, which uses a reporter enzyme inactivated by lysine modifications at an essential active site residue, thereby linking deacetylase activity to a selectable output.

Ref.-Nr.: 0707-5639-MG

Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine : Therapeutics
Nucleic Acid-, Protein and Cell-related Technologies : Nucleic acid related

Antiviral therapy against retroviruses and alphaviruses using tRNALeu(UUA) overexpression

Ref.-Nr.: 1013-5354-IKF

Analytics
Medicine : Therapeutics
Medicine : Diagnostics
Research Tools : Other
Nucleic Acid-, Protein and Cell-related Technologies : Cell related

Biomarkers of ageing have long been sought after to help assess the biological age and general health status of individuals. Considerable efforts have been invested to identify such biomarkers, including physiologic readouts, metabolic parameters, glycomic profiles and others. Nevertheless, markers with strong predictive power have remained elusive.

Work in model organisms has identified several conserved signaling pathways that extend life span, such as reduced insulin/IGF signaling and ...

Ref.-Nr.: 0401-4561-MG

Medicine : Diagnostics

Synthetic Glycosylphosphatidylinositols (GPIs) with high selectivity and purity for Toxoplasmosis diagnosis and vaccine.