Processes and Methods (incl. Screening)
A high-throughput compatible workflow for generation and analysis of homogenous human neural microtissues
Ref.-Nr.: 1012-5677-LI
Processes and Methods (incl. Screening)
File no.: MI-1012-5677-LI-ZE
(liked to MI-1012-4430-LI-ZE describing the generation of neuro- epithelial stem cells as precursors for microtissue generation)
A robust method for producing and analyzing highly homogenous human neural organoids.
A new VACCINE type able to induce STERILIZING IMMUNITY against epidemic threats caused by viruses such as SARS-CoV-2 (COVID-19) or other respiratory pathogens
Ref.-No.: 0204-3324-IKF
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine : Vaccines

"Novel first-in-class intra-nasally applicable safe recombinant "vir4vac" RNA vaccines constitute a very safe and efficacious way of preventing serious infections of respiratory corona and paramyxoviruses as well as other respiratory viruses.“
Air-stable binary Ni(0)–olefin (pre)catalyst
Ref.-Nro: 0042-5881-LC
Processes and Methods (incl. Screening) : Chemical
New Materials

A family of 16-electron binary Ni(0)-stilbene complexes Ni(Rstb)3 as a new class of air-stable Ni(0) (pre)catalysts was developed.
Do you need to shut down protein synthesis reversibly and in a cell-type specific manner?
Ref.-Nr.: 0602-5504-LI
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Research Tools : Other
Nucleic Acid-, Protein and Cell-related Technologies : Nucleic acid related
A precise and genetically encoded inhibitor for cell-type selective, inducible and reversible inhibition of protein synthesis
Exergy Efficient Chlorine Separation
Ref.-No.: 1402-5465-LC
Processes and Methods (incl. Screening) : Chemical

Three novel processes to separate Cl2 from unconverted HCl in the anode outlet stream of a electrochemical gas-phase reactor were developed at the MPI for Dynamics of Complex Technical Systems. The novel processes lead to a higher reaction yield in gas-phase reactor and have an reduced energy demand compared to the Bayer UhDenora state-of-the-art process.
Fast and efficient protein purification form prokaryotic and eukaryotic hosts
Ref.-No.: 0109-4896-LI
Processes and Methods (incl. Screening)
Fusion Tags Comprising Ubiquitin-like Modifiers and Corresponding Proteases For Protein Purification From Selected Eukaryotic Expression Hosts
Read more … Fast and efficient protein purification form prokaryotic and eukaryotic hosts
High-precision base editors for site-specific single nucleotide conversion
Ref.-No.: 0402-5782-MG
Processes and Methods (incl. Screening)
The CRISPR-Cas system is a powerful tool for site-specific genome editing. It allows for the inactivation or substitution of entire genes. However, most hereditary diseases in humans are caused by single point mutations, the correction of which requires only subtle changes to the DNA. Recently, base editors (BEs) were developed that allow the introduction of selective nucleotide substitutions. A Cas9 enzyme is fused to a nucleobase deaminase catalysing C-to-T mutations (by C-to-U deamination) ...
Read more … High-precision base editors for site-specific single nucleotide conversion
Homogenous, TR-FRET-based method for measurement of RNA- and DNA-polymerase activity
Ref.-No.: 1013-4990-IKF
Analytics
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Nucleic Acid-, Protein and Cell-related Technologies : Protein related
Nucleic Acid-, Protein and Cell-related Technologies : Cell related

An innovative high throughput screening method for measurement of RNA- and DNA-polymerase activity at room temperature, based on time-resolved FRET.
Read more … Homogenous, TR-FRET-based method for measurement of RNA- and DNA-polymerase activity
LITESEC - Light-controlled protein delivery into eukaryotic cells with high spatial and temporal resolution
Ref.-No.: 0706-5707-IKF
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine : Drug delivery
Nucleic Acid-, Protein and Cell-related Technologies : Protein related

The LITESEC-T3SS (Light-induced translocation of effectors through sequestration of endogenous components of the T3SS) system represents a novel, fast, specific, and reversible method to control protein secretion into eukaryotic cells, enabling various medicinal and biotechnological applications, such as targeted drug delivery for tumor therapy.
N-substituted pyridiniophosphines, processes for their preparation and their use
Ref.-Nr.: 0042-4938-LC-WA
Processes and Methods (incl. Screening) : Chemical
Research Tools : Other
New Materials
We offer a new family of cationic ligands, namely N-alkyl/aryl pyridiniophosphines. The ligands can be synthesized through a short, scalable, and highly modular route.
Evaluation of their electronic properties evidenced weak σ-donor and quite strong π-acceptor character when used as ancillary ligands.
Read more … N-substituted pyridiniophosphines, processes for their preparation and their use
Neuro-epithelial stem cells (NESC) capable of forming both central nervous system (CNS) and peripheral nervous system (PNS) neurons
Ref.-Nr.: 1012-4430-LI
Processes and Methods (incl. Screening)
File no.: MI-1012-4430-LI-ZE
(liked to MI-1012-5677-LI-ZE describing the generation of human neural microtissues from NECS cells)
A novel precursor population that forms electrophysiologically functional neurons more quickly than protocols starting with hPSCs.
New cell type promoting osteogenesis in bone
Ref.-No.: 1012-4727-IKF
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine
Nucleic Acid-, Protein and Cell-related Technologies : Cell related
A method to reprogram bone endothelial cells into cells that are able to mediate bone angiogenesis and osteogenesis, opening new avenues to treat osteoporosis.
New KDAC assay and selection system
Ref.-Nr.: 0803-5480-IKF
Analytics
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine : Diagnostics
Nucleic Acid-, Protein and Cell-related Technologies : Protein related

Extremely sensitive, reliable and fast novel KDAC assay, which can be performed in a continuous format. This novel KDAC assay is based on Firefly luciferase harboring an acetylation on an essential active site lysine, incorporated by genetic code expansion. We furthermore offer a bacterial selection system for KDACs, which uses a reporter enzyme inactivated by lysine modifications at an essential active site residue, thereby linking deacetylase activity to a selectable output.
Novel antiviral therapy against HIV-1 and alphaviruses: reducing frameshifting by increasing tRNALeu concentrations
Ref.-No.: 0707-5639-MG
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine : Therapeutics
Nucleic Acid-, Protein and Cell-related Technologies : Nucleic acid related

Antiviral therapy against retroviruses and alphaviruses using tRNALeu(UUA) overexpression
Ozone scrubber
Ref.-No.: 0901-5500-LC
Analytics
Processes and Methods (incl. Screening) : Chemical

Scientists in the group of Atmospheric Chemistry at the Max Planck Institute for Chemistry in Mainz have developed a novel thiosulfate based ozone scrubber to ensure accurate measurements of trace analytes. It is known from the literature that commercial potassium iodide (KI) containing ozone scrubbers can cause errors in the measurement of carbonyl compounds such as aldehydes and ketones due to byproducts formed from the oxidation of KI. Commercial ozone scrubbers based on sodium thiosulfate ...
Predicting concentrations, reactions rates and rate constants in biochemical networks
Ref.-No.: 0402-5469-MG
Analytics
IT / Software / Bioinformatics : Bioinformatics
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Nucleic Acid-, Protein and Cell-related Technologies : Protein related

A computer-implemented method that allows calculating concentration ranges of components within complex networks of biochemical reactions.
Read more … Predicting concentrations, reactions rates and rate constants in biochemical networks
Stable, site-specific conjugation of His-tagged proteins via cobalt (III) carbonate reagents
Ref.-No.: 0105-5774-IKF
Analytics
Processes and Methods (incl. Screening) : Chemical
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Research Tools : Other
Nucleic Acid-, Protein and Cell-related Technologies : Protein related

This invention relates to means and methods for conjugating/attaching target molecules such as proteins to a label and/or carrier.
Substituted Imidazolium Sulfuranes and their use as novel Electrophilic Group-Transfer Reagents
Ref.-No.: 0042-5063-LC
Processes and Methods (incl. Screening) : Chemical
Research Tools : Other
New Materials

The ability of hypervalent iodine compounds to act as electrophilic group-transfer reagents has been extensively exploited during the last several years in a variety of synthetically useful transformations
like cyanations and alkynylations. Now it was found, that novel imidazolium sulfuranes, which are isolobal to I(III) species and also depict the key threecenter four-electron bond motive, can be used as an alternative platform for the development of new electrophilic group-transfer reagents.
Imidazolium ...
SUMOvera: A Truly Orthogonal Cleavage Module
Ref.-Nr.: 0402-5439-LI
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Research Tools : Other
Nucleic Acid-, Protein and Cell-related Technologies : Protein related
SUMOvera enables versatile purification strategies for broad applications in eukaryotic hosts.
Synchrotron Serial Snapshot Crystallography of Biological Nanocrystals carried in Microscopic, Ultra-Slow, High Viscosity Free-Streams
Ref.-No.: 0105-4794-IKF
Analytics
Processes and Methods (incl. Screening) : Physical
An apparatus and method allowing high throughput collection of X-ray diffraction data at room temperature.
Ultrafast Charging-Discharging of Nano-sized Na₃V₂(PO₄)₃ Embedded in Porous Carbon Matrix for Sodium Ion Batteries
Ref.-No.: 1201-4746-LC
Processes and Methods (incl. Screening) : Chemical
New Materials

We offer the new composite nanomaterial for sodium ion battery cathodes. These carbon-coated nanosized Na3V2(PO4)3 particles embedded in a highly effective mixed conducting porous carbon matrix can be easily prepared by means of facile soft-chemistry based preparation method with a post heat treatment procedure. The resulting cathodes can be charged and discharged in 6 s with high current density of 22 A/g, deliver the specific capacity of 44 mAh/g and ...
Unique multifunctional oligonucleotide enabling ultrafast RNA-protein interactions in cells and other uses thereof
Ref.-No.: 0214-5029-MG
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Research Tools : Other
Nucleic Acid-, Protein and Cell-related Technologies : Nucleic acid related
Nucleic Acid-, Protein and Cell-related Technologies : Protein related
Unique multifunctional oligonucleotide for the ultrafast transcriptome-wide identification of RNA-binding protein (RBP) targets.