Processes and Methods (incl. Screening)

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Ref.-Nr.: 1012-5677-LI

Processes and Methods (incl. Screening)

File no.: MI-1012-5677-LI-ZE
(liked to MI-1012-4430-LI-ZE describing the generation of neuro- epithelial stem cells as precursors for microtissue generation)

A robust method for producing and analyzing highly homogenous human neural organoids.

Ref.-Nr.: 0106-5185-MG

Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine : Therapeutics
Nucleic Acid-, Protein and Cell-related Technologies : Cell related

Remodeling the morphology of mitochondria to manipulate immune cell metabolism and hence reduce immune cell activation and effector functions

Ref.-Nr.: 1305-5341-MSG

IT / Software / Bioinformatics : Bioinformatics
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine
Nucleic Acid-, Protein and Cell-related Technologies : Cell related

Cholestatic liver diseases are a heterogeneous group of disorders resulting from genetic, metabolic and congenital defects, as well as DILI (drug-induced liver injury, a leading cause of attrition during drug development).

Current diagnostic techniques for DILI and cholestasis are based on the detection of serum markers and imaging methods such as computer tomography. However, these have a low resolution and only provide a limited understanding of the underlying disease etiology. Therapeutic ...

Ref.-Nr.: 0402-3923-MG

Processes and Methods (incl. Screening)

Unicellular eukaryotic green algae from the Chlamydomonas genus are highly attractive for biotechnological production due to their rapid growth and the capability to produce high amounts of biomass at low costs. However, low expression levels of nuclear transgenes in algae have seriously limited the use of algae in production of e.g. “green chemicals”, biofuels or recombinant proteins.

Ref.-Nr.: 0602-5504-LI

Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Forschungsreagenzien : Other
Nucleic Acid-, Protein and Cell-related Technologies : Nucleic acid related

A precise and genetically encoded inhibitor for cell-type selective, inducible and reversible inhibition of protein synthesis

Ref.-No.: 0109-4896-LI

Processes and Methods (incl. Screening)

Fusion Tags Comprising Ubiquitin-like Modifiers and Corresponding Proteases For Protein Purification From Selected Eukaryotic Expression Hosts

Ref.-Nr.: 0402-5782-MG-ZE

Processes and Methods (incl. Screening)

The CRISPR-Cas system is a powerful tool for site-specific genome editing. The Cas9endonuclease is capable of introducing DNA double strand breaks at a desired location withhigh precision. The lesion is repaired either in an errorprone process leading to gene inactivation or in a highly accurate way relying on an external template. Modification of the template may serve to introduce selected mutations, modified sequencesorentirely new genes.The accurate pathway comes with low endogenous efficiency. ...

Ref.-Nr.: 0042-4938-LC-WA

Processes and Methods (incl. Screening) : Chemical
Forschungsreagenzien : Other
New Materials

We offer a new family of cationic ligands, namely N-alkyl/aryl pyridiniophosphines. The ligands can be synthesized through a short, scalable, and highly modular route.

Evaluation of their electronic properties evidenced weak σ-donor and quite strong π-acceptor character when used as ancillary ligands.

Ref.-Nr.: 1012-4430-LI

Processes and Methods (incl. Screening)

File no.: MI-1012-4430-LI-ZE
(liked to MI-1012-5677-LI-ZE describing the generation of human neural microtissues from NECS cells)

A novel precursor population that forms electrophysiologically functional neurons more quickly than protocols starting with hPSCs.

Ref.-Nr.: 0803-5480-MSG

Analytics
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine : Diagnostics
Nucleic Acid-, Protein and Cell-related Technologies : Protein related

Extremely sensitive, reliable and fast novel KDAC assay, which can be performed in a continuous format. This novel KDAC assay is based on Firefly luciferase harboring an acetylation on an essential active site lysine, incorporated by genetic code expansion. We furthermore offer a bacterial selection system for KDACs, which uses a reporter enzyme inactivated by lysine modifications at an essential active site residue, thereby linking deacetylase activity to a selectable output.

Ref.-Nr.: 0707-5639-MG

Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine : Therapeutics
Nucleic Acid-, Protein and Cell-related Technologies : Nucleic acid related

Antiviral therapy against retroviruses and alphaviruses using tRNALeu(UUA) overexpression

Ref.-No.: 0901-5500-LC

Analytics
Processes and Methods (incl. Screening) : Chemical

Scientists in the group of Atmospheric Chemistry at the Max Planck Institute for Chemistry in Mainz have developed a novel thiosulfate based ozone scrubber to ensure accurate measurements of trace analytes. It is known from the literature that commercial potassium iodide (KI) containing ozone scrubbers can cause errors in the measurement of carbonyl compounds such as aldehydes and ketones due to byproducts formed from the oxidation of KI. Commercial ozone scrubbers based on sodium thiosulfate ...

Ref.-Nr.: 0706-5433-MSG

Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Forschungsreagenzien : Other
Nucleic Acid-, Protein and Cell-related Technologies : Nucleic acid related

RNACasing: A novel and selective way of isolating and stabilizing RNA molecules, which enables processing, storing and shipping of RNA at room temperature.

Ref.-No.: 0042-5063-LC

Processes and Methods (incl. Screening) : Chemical
Forschungsreagenzien : Other
New Materials

The ability of hypervalent iodine compounds to act as electrophilic group-transfer reagents has been extensively exploited during the last several years in a variety of synthetically useful transformations
like cyanations and alkynylations. Now it was found, that novel imidazolium sulfuranes, which are isolobal to I(III) species and also depict the key threecenter four-electron bond motive, can be used as an alternative platform for the development of new electrophilic group-transfer reagents.

Imidazolium ...

Ref.-Nr.: 0402-5439-LI

Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Forschungsreagenzien : Other
Nucleic Acid-, Protein and Cell-related Technologies : Protein related

SUMOvera enables versatile purification strategies for broad applications in eukaryotic hosts.

Ref.-Nr.: 0401-5411-LC-WA

Processes and Methods (incl. Screening) : Chemical
Forschungsreagenzien : Other
New Materials

The offered thioimidazolium ionic liquids are a class of easily synthesized and harnessed alkylating agents that are completely non-volatile. The active alkylating species is produced in-situ, thus eliminating exposure and the need for specialized equipment. These features can also be used in the solid-state by their attachment to a poly(styrene) support, which allows for easy purification of the product and regeneration of the thioimidazolium alkylator and could be of special interest for flow ...

Ref.-No.: 1201-4746-LC

Processes and Methods (incl. Screening) : Chemical
New Materials

We offer the new composite nanomaterial for sodium ion battery cathodes. These carbon-coated nanosized Na3V2(PO4)3 particles embedded in a highly effective mixed conducting porous carbon matrix can be easily prepared by means of facile soft-chemistry based preparation method with a post heat treatment procedure. The resulting cathodes can be charged and discharged in 6 s with high current density of 22 A/g, deliver the specific capacity of 44 mAh/g and ...